Week 2, 2026 · Jan 5 – Jan 11

Top 40

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Genomics

Knowledgebases now map regulatory elements and GWAS variants onto genes and traits

ML / AI methods

Curated databases structure microbial habitat, antigen, lysin and biosynthetic gene data

Systems biology

Inhibitory integration, burst-driven weight attractors, and Φ in spiking networks

Proteomics

Spatial statistics and dimension reduction resolve molecular patterns in omics data

Tools & infrastructure

Curated databases pair bioactivity records with structural and mechanistic annotation

6 Immune atlases map inflammatory and cytotoxic cell states across disease and agingSingle-cell

7 Databases annotate TE-initiated transcripts in cancer and enhancer perturbationsML / AI methods

8 Fusing sequence, structure and graph features for multimodal interaction predictionML / AI methods

9 Learned models expand protein conformational sampling and sequence-energy fittingStructural bio & protein design

10 Expert curation anchors scalable annotation of biomedical literature and omics metadataTools & infrastructure

11 Deep learning automates particle picking, fusion, and event detection in microscopyStructural bio & protein design

13 Repeats and chromatin context shape genome architecture and regulatory variationEpigenomics

14 DFT reference data refines torsion parameters and hybrid ML/MM simulation setupStructural bio & protein design

15 Deep learning links routine histology and multi-omics to cancer biomarkersML / AI methods

16 Software tools for batch correction, cfDNA fragment analysis and proteomics QCTools & infrastructure

17 Atlases and tools link GWAS loci and QTLs to cell types, pathways, and mechanismsGenomics

18 Curated RNA resources and nanopore methods map circRNA modifications and interactionsTools & infrastructure

19 Browser and agent-driven tools standardize EV, transcriptomic and omics plotting workflowsTools & infrastructure

20 LLMs as reasoning and agentic components in drug discovery workflowsML / AI methods

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21 Somatic variants joined to dependency and single-cell context for target nominationML / AI methods

22 Deep models for single-cell perturbation, annotation, and foundation-model interpretationML / AI methods

23 Automated curation and standardization of small-molecule data for predictive modelingTools & infrastructure

24 Chromosome-scale and pangenome assemblies advance fungal and polyploid crop genomicsGenomics

25 AI structure models extended to protein conformational dynamics and ensemble samplingStructural bio & protein design

26 Gap-free assemblies and pangenomes expose structural variation across crop lineagesGenomics

27 Protonation and ion handling shape membrane transport and penetration in MD simulationsStructural bio & protein design

28 Stochastic variability and network structure set cellular timing and sizeSystems biology

29 Physical polymer models connect 3D genome organization to regulatory outputEpigenomics

30 Automated pipelines convert raw sequence data into queryable, reusable genomic resourcesTools & infrastructure

31 Tissue-wide planar cell polarity emerges from local signals in cellular Potts modelsSystems biology

32 Proteome-wide annotation and structure-based tools advance protein function inferenceTools & infrastructure

33 Spectral libraries and origin-aware annotation advance LC-MS metabolomicsMetabolomics

34 Sequence patterning governs peptide condensation and membrane translocationStructural bio & protein design

35 Learned multi-omics integration spans single-cell clustering and patient survivalSingle-cell

36 Tissue-resolved metabolic models, spatial lipidomics, and curated MASH transcriptomicsMetabolomics

37 ML rescoring and mass offset search refine peptide and PTM identification from MS/MSProteomics

38 Reference benchmarks and Bayesian models quantify variant call and effect reliabilityGenomics

39 New callers resolve CNVs, structural variants, uniparental disomy and aneuploidy from NGSGenomics

40 Genome-scale constraint maps proto-gene precursors and duplicate-gene divergenceGenomics

Week 2, 2026 · Jan 5 – Jan 11

Top 40

Knowledgebases now map regulatory elements and GWAS variants onto genes and traits

Curated databases structure microbial habitat, antigen, lysin and biosynthetic gene data

Inhibitory integration, burst-driven weight attractors, and Φ in spiking networks

Spatial statistics and dimension reduction resolve molecular patterns in omics data

Curated databases pair bioactivity records with structural and mechanistic annotation

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