Atlases and tools link GWAS loci and QTLs to cell types, pathways, and mechanisms

Published papers

• Protein-protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits.

  Nature genetics2026-01-07Jinghui Li et al.

  Re-analyzes large pQTL maps and uses PPI annotations to guide trans-pQTL mapping, identifying 17,662 trans-pQTLs linked to GWAS loci.

• SGCRNA: spectral clustering-guided co-expression network analysis without scale-free constraints for multi-omic data.

  Briefings in bioinformatics2026-01-07Tatsunori Osone et al.

  SGCRNA is a Julia tool for co-expression network analysis that avoids WGCNA's scale-free assumption and tuning requirements, addressing slope neglect in…

• Spatial2GWAS: a database for linking spatial transcriptomic regions with GWAS traits.

  Nucleic acids research2026-01-06Xi Hu et al.

  Spatial heterogeneity of gene expression within tissue regions has a critical influence on biological functions, thereby affecting disease pathogenesis.

• GENEasso: a curated resource of credible disease-gene associations across complex diseases from GWAS summary statistics.

  Nucleic acids research2026-01-06Tao Jiang et al.

  Gene-based association analysis has become a powerful strategy to improve the biological interpretability of genome-wide association studies (GWAS) by aggregati

• Spatial GWAS Atlas: a knowledgebase for decoding the genetic architecture of complex traits in spatial resolution.

  Nucleic acids research2026-01-06Hongen Kang et al.

  Spatial GWAS Atlas is a knowledgebase linking 3854 GWAS summary statistics to 635 spatial transcriptomics datasets to map trait-associated cells and spatial…

• scVMAP: a comprehensive platform for integrating single-cell chromatin accessibility regions with causal variants.

  Nucleic acids research2026-01-06Zheng-Min Yu et al.

  Integrating causal variant effects with single-cell assay for transposase-accessible chromatin with high-throughput sequencing (scATAC-seq) enables a more effec

• DisCP-Atlas: a comprehensive resource mapping cellular processes to complex diseases.

  Nucleic acids research2026-01-06Frank Qingyun Wang et al.

  Genome-wide association studies (GWAS) have identified thousands of disease-associated loci, yet translating these findings into biological mechanisms remains c

• TWAS atlas 2.0: an updated data resource for transcriptome-wide association studies.

  Nucleic acids research2026-01-06Hao Gao et al.

  Transcriptome-wide association studies (TWAS), which combine large-scale GWAS and expression quantitative trait loci (eQTL) datasets to predict gene expression

• Uncovering coordinated pathway interactions through gene co-differential expression in yeast.

  Nucleic acids research2026-01-05Muhammad Ibtisam Nasar et al.

  YeastCoDEGNet: a co-differential expression network from 143 curated yeast microarray experiments, linking genes and pathway modules.

• Chinese Immune Multi-Omics Atlas.

  Science (New York, N.Y.)2026-01-08Jianhua Yin et al.

  CIMA is a multi-omics atlas of over 10 million circulating immune cells from 428 Chinese adults, with a gene regulatory network, eQTL/caQTL maps, and a cell…

Related topics

• Genetic Architecture Knowledgebases
• Cell Type Resolved Omics Atlases
• Genomic Data Analysis Software

Topic history