Top 40
View all ›BACKFILLED Code and industry signals are partial for backfilled days.
Rank 1
Single-cell
Structure-preserving representations for spatial and single-cell omics across modalities
Spatial and single-cell omics methods now encode resolution, quality, and batch structure, exposing where learned representations still fail.
16 preprints · 2 published · ↑ 2.8× vs 4-wk avg
Rank 2 Structural bio & protein design
Pretrained sequence language models applied to protein, mRNA and DNA tasks
Recent preprints benchmark large pretrained sequence models on fitness, stability, and design tasks across proteins, mRNA and DNA.
7 preprints · 2 published · ↑ 2.3× vs 4-wk avg
Rank 3 Genomics
Open software tools for single-cell DNA, lentiviral integration, and leukemia data
Recent releases extend analysis software from data processing into gene therapy safety surveillance and leukemia subtype prediction.
5 preprints · 2 published · ↑ 2.2× vs 4-wk avg
Rank 4 Tools & infrastructure
Tools convert MS, metabolomics, and RNA-seq outputs into analysis-ready formats
Recent preprints and one published tool target parsing, validation, and workflow integration for multi-platform omics outputs.
4 preprints · 1 published · ↑ 1.9× vs 4-wk avg
Rank 5 Genomics
Genome and metagenome mining links microbial sequence content to function and host state
Expanded genome, metagenome, and pangenome collections now enable trait assignment from broad microbial sampling rather than aggregate diversity alone.
4 preprints · 3 published · ↑ 1.8× vs 4-wk avg
Rank 6 Experimental restraints and force fields refine RNA and peptide conformational ensembles↑ 1.8×Structural bio & protein designRank 7 Graph attention over biomedical networks predicts interactions and perturbation effects↑ 1.5×ML / AI methodsRank 8 Computational mini-protein binder design and epitope selectivity scoring for viral targetsStructural bio & protein designRank 9 Learned models score neoepitope immunogenicity and antibody developabilityML / AI methodsRank 10 Selection and phage-bacteria dynamics shape bacterial and phage genetic variation↑ 1.6×GenomicsRank 11 Residue-level descriptors assess AlphaFold prediction quality and domain environmentsStructural bio & protein designRank 12 Learned visual representations for cell and tissue analysis in biomedical imagingML / AI methodsRank 13 Modular tools scale sequence alignment and Z-nucleic acid mapping across genome datasetsTools & infrastructureRank 14 Attention models predict bacterial resistance, protein-ligand affinity and interactionsML / AI methodsRank 15 Scalable summary-statistics methods for heritability, genetic correlation, ancestryGenomicsRank 16 Recovering temporal and periodic structure from static single-cell measurementsSingle-cellRank 17 Intrinsic noise and delays shape timing, bistability, and adaptation in gene networksSystems biologyRank 18 Nanopore direct RNA sequencing calibration sharpens RNA modification site callingSingle-cellRank 19 Pangenome, acrocentric, and microRNA studies link structural genome change to functionGenomicsRank 20 Mechanical models couple cellular forces, flow and confinement to cell morphologySystems biology
Show 15 more
Rank 21 Deep learning decodes EEG markers of consciousness, language coherence and predictionML / AI methodsRank 22 Primer design and reference tools refine targeted sequencing assay specificity and…Tools & infrastructureRank 23 Benchmarking omics methods and candidate biomarkers against reference standardsML / AI methodsRank 24 Learned models predict protein-ligand affinity and drug-drug interactionsML / AI methodsRank 25 Chemist-style cues and shortcut learning complicate activity model benchmarkingML / AI methodsRank 26 Interaction structure sets extinction, cooperation, and ecosystem outcomes across systemsSystems biologyRank 27 Deep learning variant models move toward noncoding and protein interaction effectsGenomicsRank 28 Pretrained transformers and all-atom predictors repurposed for molecular and peptide…Structural bio & protein designRank 29 Haplotype-resolved and T2T references reshape alignment and trait-gene discoveryGenomicsRank 30 Single-cell and haplotype-aware tools for CRISPR editing and cardiac regenerationTools & infrastructureRank 31 MD simulations map residue-level determinants of amyloid aggregation and inhibitionStructural bio & protein designRank 32 Explicit computational models of cell and tissue systems tested against experimental dataSystems biologyRank 33 Polarizable simulation and AlphaFold 3 sharpen nucleic acid binding and structure modelsStructural bio & protein designRank 34 Haplotype-resolved assemblies of wild relatives map disease and pest resistance lociGenomicsRank 35 Testing genomic and causal factors within multi-omics networks and molecular programsSystems biology