November 2026 · so far

Top 40

Tools & infrastructure

Curated portals, databases and workflows consolidate spatial and single-cell data for…

Single-cell

Frozen single-cell foundation models extended to multimodal completion and reconstruction

Single-cell

Single-cell perturbation response models are coupled to regulatory, pathway and temporal…

Tools & infrastructure

Cell-, tissue- and spatially resolved omics atlases enable deconvolution, causal…

Transcriptomics

Separating spatial context from cell identity in spatial transcriptomic variation

6 Generative models produce protein conformational ensembles guided by experimental dataStructural bio & protein design

7 Curated resources link experimental binding and specificity data to molecular structuresTools & infrastructure

8 Reference choice and tissue-aware models reshape somatic variant detection across human…Genomics

9 LLM agents and biological models are being tested and constrained against explicit…ML / AI methods

10 Curated microbial genome and metagenome resources support strain, plasmid and metabolic…Tools & infrastructure

11 Pretrained and conditioned models guide DNA, RNA, protein, and antibody designML / AI methods

12 Sequence-to-function models are fine-tuned and extended to score noncoding variants at…Epigenomics

13 Transcriptomic models are evaluated by transfer design, calibration and identifiabilitySingle-cell

14 Modeling glioblastoma invasion and proliferation from MRI and single-cell imaging dataSystems biology

15 New isoform quantification methods reduce mapping ambiguity and are benchmarked against…Transcriptomics

16 Assay-aware and protocol-matched ML models for prioritizing small moleculesML / AI methods

17 LLM agents ground omics and clinical genomic analysis in executable skills, memory, and…ML / AI methods

18 Statistical methods for microbiome inference under compositionality and confoundingML / AI methods

19 Graph pangenomes and simulation reveal structural variation driving genome evolutionGenomics

20 Coupled Models Link Chromatin Organization to Hydration and Cohesin KineticsEpigenomics

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21 Learned scores prioritize protein variants, binding pockets and complex interfacesStructural bio & protein design

22 Inferring unmeasured spatial omics layers from histology, transcripts and host signalsML / AI methods

23 Learned and accelerated methods now operate directly on raw reads and pileupsSingle-cell

24 Metabolic measures linked to genetic and clinical evidence in large human resourcesGenomics

25 Computational tools standardize benchmarking and interpretation of variantsTools & infrastructure

26 Imaging and spatial data tools embed attribution, heterogeneity modeling and benchmarkingML / AI methods

27 Structural modelling links disease-associated variants to altered protein featuresStructural bio & protein design

28 Local learning and low-rank subspaces explain model-brain alignmentML / AI methods

29 Mechanical and diffusive forces modelled as generators of tissue and pattern geometrySystems biology

30 Jagged-end correction for cfDNA methylation profiling preserves duplex integrityEpigenomics

31 Curated databases catalog cell markers, enhancers, tRNA modifications and lncRNAs across…Tools & infrastructure

32 Molecular profiles are being linked to individual clinical outcome predictionsSingle-cell

33 Explicit reference criteria for evaluating biological model outputs and representationsEpigenomics

34 Deep learning models decode 3D chromatin architecture from Hi-C contact matricesEpigenomics

35 Bursty production shapes timing, rhythm transmission and signaling informationSystems biology

36 Whole-genome doubling tracked as subclonal evolution across human cancersEpigenomics

37 Auditable predictions for protein yield, structure search, and proteome recodingStructural bio & protein design

38 Parameter degeneracy and bursting transitions in minimal neuron and population modelsSystems biology

39 Chromosome-scale genomes reveal organelle-host metabolism and sex chromosome evolutionGenomics

40 Learned priors and fragment-ion evidence under validation in MS/MS identificationMetabolomics

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