Top 40
View all ›BACKFILLED Code and industry signals are partial for backfilled days.
Rank 1
Single-cell
Structure-anchored representation learning for spatial and single-cell omics
Recent preprints address alignment, batch correction, deconvolution, and quality control across spatial and single-cell omics modalities and scales.
12 preprints · 1 published · ↑ 2.6× vs 4-wk avg
Rank 2 Systems biology
Mechanical models couple cell confinement, cytoplasmic flow and forces to morphology
Recent preprints pair cell-scale mechanical models with confinement, flow and Bayesian force-inference tools to predict and infer cell behavior.
4 preprints · ↑ 2.3× vs 4-wk avg
Rank 3 ML / AI methods
Open software spans single-cell DNA, integration site safety, and leukemia modeling
Recent preprints extend analysis tooling into single-cell DNA subclonality, lentiviral integration safety, and T-ALL transcriptome classification.
4 preprints · 1 published · ↑ 2.0× vs 4-wk avg
Rank 4 Tools & infrastructure
Software tools bridging omics platform outputs and downstream analysis workflows
Platform- and engine-specific omics outputs require automated conversion, validation, and annotation before downstream analysis can proceed.
5 preprints · ↑ 2.0× vs 4-wk avg
Rank 5 Genomics
Genome and metagenome mining links microbial sequence content to function and ecology
Expanding genome, metagenome, and protein-family collections now allow specific trait classes to be assigned from broad environmental and host sampling.
4 preprints · 3 published · ↑ 1.7× vs 4-wk avg
Rank 6 Structure-aware networks target binding interfaces, mutation stability, and molecular…↑ 1.7×Structural bio & protein designRank 7 Computational tools prioritize tumor neoantigens from sequencing and immunopeptidomics↑ 1.7×ML / AI methodsRank 8 Pretrained protein models adapted for stability, design, and conformational sampling↑ 1.5×Structural bio & protein designRank 9 Benchmarking docking, FlexS, and deep learning methods for coronavirus Mpro binding↑ 1.6×Structural bio & protein designRank 10 Experimental restraints and force fields refine biomolecular conformational ensembles↑ 1.6×Structural bio & protein designRank 11 LLM agents orchestrate computational tools across drug discovery and spatial biology…ML / AI methodsRank 12 Phage and selection models link bacterial population dynamics to genome evolution↑ 1.6×GenomicsRank 13 Nanopore direct RNA workflows refine modification site calling accuracySingle-cellRank 14 Foundation and deep models advance cell phenotyping and subtyping in biomedical imagesML / AI methodsRank 15 Graph models integrate multi-omics and interaction networks to predict molecular linksSystems biologyRank 16 New tools for scalable genome-scale sequence alignment, assembly and annotationTools & infrastructureRank 17 Individualized brain network models and multivariate comparison of subject parcellations↑ 1.5×ML / AI methodsRank 18 Designed minibinders reach nanomolar affinity for viral receptor-binding domainsStructural bio & protein designRank 19 Deep models predict bacterial resistance, protein interactions, and microbial protein…ML / AI methodsRank 20 Scalable methods for heritability, ancestry inference, and multi-omics outcome modellingGenomics
Show 18 more
Rank 21 Generative models design cell-type-specific enhancers validated in vivoML / AI methodsRank 22 Biological sequence language models span protein fitness, mRNA design and DNA functionML / AI methodsRank 23 Network structure and interactions shape epidemic, cooperative, and ecosystem outcomesSystems biologyRank 24 AlphaFold model quality assessed via residue neighborhoods and pLDDT fragmentationStructural bio & protein designRank 25 Open tools refine primer design and viral enrichment for targeted sequencingTools & infrastructureRank 26 Inferring dynamics and periodic phases from static single-cell snapshotsSingle-cellRank 27 Intrinsic noise shapes timing precision and metastability in gene regulatory networksSystems biologyRank 28 T2T-CHM13 cuts mapping bias while new haplotype and pangenome assemblies appearGenomicsRank 29 Mechanistic models link vasculature, immune dynamics and drug delivery in tumour therapySystems biologyRank 30 Explicit mechanistic models of promoter, stress-response and allosteric dynamicsSystems biologyRank 31 Simulations localize residue-specific aggregation determinants in amyloidogenic proteinsStructural bio & protein designRank 32 Quantitative models link cell cooling, ciliary flow and corneal epithelial homeostasisSystems biologyRank 33 Web-accessible tools now map brain coordinates, model neurons, and quantify morphologyTools & infrastructureRank 34 Reference-guided and parental-free methods resolve haplotypes in heterozygous genomesGenomicsRank 35 Structural variation and evolution reshape genome architecture and microRNA repertoiresGenomicsRank 36 Haplotype-resolved assemblies of hickory, Aegilops and Vitis enable resistance mappingGenomicsRank 37 Simulations assess how ligands and predicted structures engage RNA and DNA binding sitesStructural bio & protein designRank 38 Learned models extend Bacillus biosynthesis analysis from genomes to literature miningGenomics