Top 40
View all ›BACKFILLED Code and industry signals are partial for backfilled days.
Rank 1
ML / AI methods
Learned representations couple cell-gene and spatial constraints in omics analysis
Recent December 2025 preprints and publications extend learned representations to spatial, single-cell, and morphological profiling data.
7 preprints · 5 published · ↑ 2.6× vs 4-wk avg
Rank 2 Genomics
Chromosome-scale assemblies link genome architecture to size and evolutionary history
Near-complete and chromosome-scale assemblies now resolve structural variation, repeat content and centromere organisation across diverse taxa.
4 preprints · 3 published · ↑ 2.4× vs 4-wk avg
Rank 3 Single-cell
Methods correcting batch, segmentation and reference effects in single-cell analysis
Recent preprints and publications extend single-cell and spatial tools to batch-aware gene selection, transcript correction, and sample-level embeddings.
8 preprints · 5 published · ↑ 2.1× vs 4-wk avg
Rank 4 ML / AI methods
Guidance, synthesis constraints, and foundation-model priors steer molecular design
Recent preprints encode design criteria directly into generative and selection loops for protein, small-molecule, and PROTAC design.
6 preprints · 2 published · ↑ 2.0× vs 4-wk avg
Rank 5 ML / AI methods
Graph and language-model learning advance drug-target interaction prediction
Recent work pairs graph neural networks with knowledge graphs, optimal transport and language-model embeddings for scarce-label interaction prediction.
2 preprints · 3 published · ↑ 1.9× vs 4-wk avg
Rank 6 Genome-scale models link bacterial gene content to metabolic function and flux↑ 1.7×Systems biologyRank 7 Multiscale MD maps chemerin-CCRL2 interface and GumK substrate gating at residue level↑ 2.0×Structural bio & protein designRank 8 Evaluating omics analysis pipelines against known reference points and benchmarks↑ 1.7×ProteomicsRank 9 Model-based estimators recover structure from noisy single-cell and omics measurements↑ 1.8×ML / AI methodsRank 10 Single-cell transcriptomics attributes genetic, disease and drug effects to specific cell…↑ 1.7×Single-cellRank 11 Non-additive and regulatory models partition genetic architecture of complex traits↑ 1.7×GenomicsRank 12 Latent neural representations spanning scales, modalities and recording types↑ 1.7×ML / AI methodsRank 13 Sampling structure and database cutoffs shape ML predictions of bacterial resistance↑ 1.7×ML / AI methodsRank 14 RBP binding at exon flanks links exon inclusion to histone marks↑ 1.6×EpigenomicsRank 15 Structure predictors lose reliability outside ordered folds: disordered multimers,…↑ 1.6×Structural bio & protein designRank 16 Reference-benchmarked tools for nanopore RNA modification and long-read isoform analysis↑ 1.6×TranscriptomicsRank 17 Explicit quantitative models linking circuit parameters to observed neural dynamics↑ 1.6×Systems biologyRank 18 Machine learning maps molecular and clinical features to cancer drug response↑ 1.5×ML / AI methodsRank 19 Graph and language-model encodings of biomolecular structure for pattern discovery↑ 1.5×ML / AI methodsRank 20 Agentic LLMs and multimodal embeddings are being built into omics analysis workflowsTools & infrastructure
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Rank 21 Learned and theoretical spectral models improve identifications from raw MS dataProteomicsRank 22 Functional annotation and cross-disorder transfer refine GWAS locus discoveryGenomicsRank 23 Stereochemistry-aware metabolite assignment and atom provenance in reaction networksMetabolomicsRank 24 Structure-conditioned design extends to antibodies, peptides, and small-molecule bindersStructural bio & protein designRank 25 Automated and learned variant classification methods for germline and tumour-only dataTools & infrastructureRank 26 Long-read sequencing resolves variation in human centromeres, telomeres, and rDNAGenomicsRank 27 Established indexing primitives recombined for pangenome alignment and k-mer storageGenomicsRank 28 Chromatin and mitotic folding models coupled to measured observablesEpigenomicsRank 29 Sequence-based typing resolves bacterial strain lineages and pathogen AMR genesGenomicsRank 30 Energy models of nucleic acid structure predict Cas9 cleavage and RNA folding under forceStructural bio & protein designRank 31 Haplotype blocks and 3D structure are being packaged as analysis softwareTools & infrastructureRank 32 Omics software tools target benchmarking, genomic interval operations and data standardsTools & infrastructureRank 33 Neural parameterization of explicit mechanisms for reaction and gene regulatory dynamicsSystems biologyRank 34 Biophysical models quantify conduction and spinal blood flow changes in silicoSystems biologyRank 35 Assembly reliability and lifestyle shape fungal and viral genome resourcesGenomicsRank 36 Noise control and propagation shape transcriptional switching and causal gene inferenceSystems biologyRank 37 Correcting genotyping and methylation array platform effects in genomic inferenceEpigenomicsRank 38 Coupled behavioral and network epidemic models with proven threshold and stabilitySystems biologyRank 39 Standardized feature scoring extends from bulk expression to isoforms and chromatinSingle-cellRank 40 Genomes resolve phototrophy, marine ecotypes, and a deep-branching algal lineageGenomics