#36 · Systems biology

Network and generative models of AML treatment response and drug design

The dominant thread is an explicit computational model serving as the inferential core for therapeutic questions. Two AML preprints apply this to treatment and drug design: an edge-weighted digraph framework models cytarabine treatment contextuality and explores SAMHD1 inhibitors, with a web-based interface, while a metaheuristic fragment-assembly pipeline generates ligands against AlphaFold3-modeled, WGCNA-prioritized biomarkers and tests them by docking. The published gMIS work is not AML-specific. It extends minimal intervention set formulations from gMCS to knockouts and knock-ins across integrated metabolic-regulatory networks. What is new across the set is that the model structure itself, rather than only its output, becomes the analytical object.