Top 40
View all ›BACKFILLED Code and industry signals are partial for backfilled days.
Rank 1
Single-cell
Deep generative models separate biological variation in single-cell and spatial omics
Recent work pairs disentangled latent models with causal, spatial and foundation-model designs to isolate biological factors in single-cell data.
10 preprints · 4 published · ↑ 2.3× vs 4-wk avg
Rank 2 Tools & infrastructure
Software refines microbiome profiling from 16S references to metagenome annotation
Recent preprints and publications extend reference curation, annotation, differential abundance, and functional recovery tools for microbiome analysis.
7 preprints · 3 published · ↑ 1.7× vs 4-wk avg
Rank 3 Structural bio & protein design
Generative models design molecules against explicit objectives and realism checks
Benchmarks against confirmed actives and synthesis-aware scoring now test whether generated molecules are realistic, not merely produced.
4 preprints · 4 published
Rank 4 Single-cell
Single-cell trajectories are modeled for differential expression and regulatory inference
Single-cell trajectory data now support pseudotime-aware differential expression, regulatory network inference, and pathway activity scoring.
5 preprints · 3 published
Rank 5 Genomics
Long-read methods expand detection of structural, mitochondrial and complex variation
Long-read sequencing now enables local assembly, target-free allele reconstruction, and methylation-aware phasing across diverse variant classes.
7 preprints · 1 published
Rank 6 Multimodal spatial and single-cell atlases map healthy and developing human tissuesSingle-cellRank 7 Inferring regulatory activity from splicing, chromatin, and cfDNA dataEpigenomicsRank 8 Graph and Transformer representations advance molecular generation and property predictionML / AI methodsRank 9 SE(3) diffusion models extend to antibody design, docking, and protein dynamicsStructural bio & protein designRank 10 LLM frameworks integrate biological knowledge and multimodal data for prediction tasksML / AI methodsRank 11 Label-efficient models segment nuclei, ultrastructure and cells in microscopy imagesML / AI methodsRank 12 Feedback and criticality buffer cellular outputs against perturbation in biological…Systems biologyRank 13 Deep models for DNA and RNA sequence-to-function prediction and benchmarkingML / AI methodsRank 14 Machine learning prioritizes antibacterial peptides and cyanine dyes for testingML / AI methodsRank 15 Graph-based multimodal learning predicts protein function and drug-target interactionsML / AI methodsRank 16 Web-accessible tools now packaging RNA, microbial genomics, and amplicon analysesTools & infrastructureRank 17 Deep learning models infer genotype and subtype from histopathology and omics dataML / AI methodsRank 18 Neural models learn directly from raw sequencing and genomic dataML / AI methodsRank 19 Automated pipelines recover viral genomes and filter artifacts from large sequence setsTools & infrastructureRank 20 Physics-informed and geometry-constrained models target biomolecular conformationsStructural bio & protein design
Show 16 moreShow less
Rank 21 Computational tools map sequence variation to protein folding and function effectsStructural bio & protein designRank 22 Constrained models and Bayesian networks are tested for inference from biological dataSystems biologyRank 23 Mechanistic models link resource supply, vector traits, and resistance to persistenceSystems biologyRank 24 Simulation-ready preparation of predicted and sampled biomolecular structures for MDStructural bio & protein designRank 25 Linking neuronal metabolism, callosal genetics, and imaging pipelines to brain diseaseTools & infrastructureRank 26 Local rules and connectivity set emergent dynamics in neural and tissue systemsSystems biologyRank 27 Optimized non-equispaced sampling improves detection of biological rhythmsSystems biologyRank 28 Network, Boolean and spatial models prioritize cancer therapeutic targetsSystems biologyRank 29 MD simulations resolve conformational switching in ezrin, σ2R homodimers, and NLRP3Structural bio & protein designRank 30 Text mining and reanalysis tools turn public biomedical data into queryable networksTools & infrastructureRank 31 MD simulations map allosteric routes in nucleosome and RNA polymerase II complexesStructural bio & protein designRank 32 Consistent tree inference under discordance paired with pandemic-scale confidence…GenomicsRank 33 Optimal transport geometry quantifies biological shape from skulls to proteinsStructural bio & protein designRank 34 Open-source tools convert lipidomics, GNPS, and MRS data into interpretable outputsMetabolomicsRank 35 Inferring parameters and interaction structure of biological dynamical models from dataSystems biologyRank 36 Mechanistic models of immunity waning, reinfection, and staged viral processesSystems biology