Top 40
View all ›BACKFILLED Code and industry signals are partial for backfilled days.
Rank 1
ML / AI methods
Domain-informed molecular representations advance property and interaction prediction
Recent work encodes domain structure into molecular graphs and sequences for generation, reaction prediction and drug-target interaction tasks.
9 preprints · 4 published · ↑ 2.3× vs 4-wk avg
Rank 2 Single-cell
Generative and foundation models separate biological variation in single-cell data
Recent models encode explicit biological structure, such as circular cell-cycle subspaces and causal networks, directly into generative architectures.
7 preprints · 5 published · ↑ 2.1× vs 4-wk avg
Rank 3 Tools & infrastructure
Curated references and consensus statistics refine microbial profiling tools
Recent preprints and publications address reference database errors, limits of metagenomic functional recovery, and viral genome classification.
6 preprints · 3 published · ↑ 1.7× vs 4-wk avg
Rank 4 ML / AI methods
Label-efficient segmentation across histology, electron and multiplexed microscopy
Recent preprints apply self-supervised, self-training and foundation-model fine-tuning to nuclei, niche, ultrastructure and cell segmentation tasks.
8 preprints · 1 published · ↑ 1.7× vs 4-wk avg
Rank 5 ML / AI methods
Interpretable models predict regulatory activity and variant effects from DNA sequence
Genomic deep learning work increasingly pairs predictive accuracy with explanations of regulatory and variant-level outputs.
6 preprints · 2 published · ↑ 1.6× vs 4-wk avg
Rank 6 Inferring regulatory activity from splicing, fragmentation, and population-scale data↑ 1.6×Single-cellRank 7 Feedback and canalization buffer biological network outputs against perturbationSystems biologyRank 8 Learned models infer cancer subtypes and cell states from omics and histology dataML / AI methodsRank 9 Computational methods map spatial cell neighborhoods and pathway activity in tissuesSingle-cellRank 10 MD simulations map dynamic allosteric routes across nucleic acid and protein assembliesStructural bio & protein designRank 11 Predictive and network-analysis software for microbiome, epigenomic, and cancer dataTools & infrastructureRank 12 Physical and geometric constraints shape biomolecular prediction and design modelsStructural bio & protein designRank 13 Computational tools translate sequence variation into predicted protein-level effectsStructural bio & protein designRank 14 Machine learning prioritizes antimicrobial peptides and cyanine antibiotics for testingML / AI methodsRank 15 Single-cell atlases resolve cell-type diversity across human organs and mouse developmentSingle-cellRank 16 Deep learning predicts MS/MS spectra for PTMs, small molecules and DIA librariesProteomicsRank 17 Coupling LLMs with biological structure and imaging features for prediction tasksML / AI methodsRank 18 Inferring parameters and interactions of biological dynamical models from quantitative…Systems biologyRank 19 LLM agents and multimodal embeddings are querying public transcriptomic dataSingle-cellRank 20 Graph-based multimodal models predict protein function and drug-target interactionsML / AI methods
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Rank 21 Neural models read raw sequencing, microscopy, and alignment data directlyML / AI methodsRank 22 Evaluating inferred biological structure against simulated and benchmark ground truthSystems biologyRank 23 Tunable dosing, vector, noise, and supply inputs set population persistence outcomesSystems biologyRank 24 Preparing predicted structures for molecular dynamics and trajectory analysisStructural bio & protein designRank 25 Software tools for genomic neighbourhoods, RNA structure, and pan-genome analysisTools & infrastructureRank 26 Local rules and crosslink disorder give rise to emergent collective dynamicsSystems biologyRank 27 Phylogeny-based and error-filtering pipelines for large eukaryotic sequence datasetsGenomicsRank 28 Long reads and methylation refine haplotype phasing and mitochondrial variant analysisGenomicsRank 29 Computational models link tissue stiffness and anisotropy to organ mechanics and transportSystems biologyRank 30 Cortical dynamics shape neuronal tuning heterogeneity and trial-to-trial variabilitySystems biologyRank 31 Mechanistic and neural ODE models link preclinical data, pathway kinetics and survivalSystems biologyRank 32 Specificity-aware tools for microbial probe design, signature discovery and annotationTools & infrastructureRank 33 Temporal inference of aging dynamics across clinical, ovarian, and single-cell dataSingle-cellRank 34 Consistent tree inference under discordance paired with pandemic-scale confidenceGenomicsRank 35 Long-read tools reconstruct alleles and resolve chromatin base modificationsEpigenomicsRank 36 Open-source tools turn lipidomics, MS/MS, and MRS spectra into interpretable outputsMetabolomics