Top 40
View all ›BACKFILLED Code and industry signals are partial for backfilled days.
Rank 1
Genomics
Repeat-aware and callable-loci tools reshape diversity, selection, and variant analysis
Recent tools address repeats, haplotypes, and population statistics directly from long-read, short-read, and variant-only data.
2 preprints · 8 published · ↑ 2.9× vs 4-wk avg
Rank 2 ML / AI methods
Structure-aware models extend protein design, docking, and fitness prediction
Structure-conditioned generative and multimodal encoders are improving protein design, docking, and function prediction from limited labels.
5 preprints · 3 published · ↑ 2.3× vs 4-wk avg
Rank 3 Systems biology
Fitted whole-brain and neural mass models judged against independent neural recordings
Recent preprints evaluate fitted whole-brain and neural mass models against neural data beyond the original fit, testing their explanatory reach.
5 preprints · 1 published · ↑ 2.3× vs 4-wk avg
Rank 4 Transcriptomics
Spatial multi-omics maps prognostic tumor niches and benchmarks spatial transcriptomics
Spatially resolved multi-omics and H&E-based prediction now link localized tumor niches to prognosis in female genital tumors.
10 preprints · 2 published · ↑ 2.1× vs 4-wk avg
Rank 5 Systems biology
Mechanical loading as a quantitative input to multiscale tissue models
Four recent preprints couple stress inference, bond-level kinetics and multiscale simulation to quantify tissue mechanics across systems.
4 preprints · ↑ 2.3× vs 4-wk avg
Rank 6 Structural models of multimeric nanopores and computational interface analysis tools↑ 1.9×Tools & infrastructureRank 7 Inference for stochastic and deterministic mechanistic biological models↑ 1.8×Systems biologyRank 8 Biologically informed tokenization and patching reshape DNA language model inputs↑ 1.7×ML / AI methodsRank 9 Transformer and generative models reconcile unpaired and multimodal single-cell dataSingle-cellRank 10 Pretrained embeddings drive molecular prediction; evaluation design is under scrutiny↑ 1.6×ML / AI methodsRank 11 Multi-omics frameworks reduce multimodal data to ranked biomarker and gene candidates↑ 1.6×Systems biologyRank 12 Deep learning links tumor measurements to mutations, survival, and therapy response↑ 1.5×ML / AI methodsRank 13 Calibrated GWAS methods sharpen fine-mapping, rare-variant and regulatory analysis↑ 1.6×GenomicsRank 14 Audits of genomic and protein predictors probe confounders, leakage and motif bias↑ 1.5×ML / AI methodsRank 15 Prior-structured models tackle zero-inflated, compositional, and dynamic microbiome data↑ 1.5×ML / AI methodsRank 16 Reference data, negative sets and feature choice govern binding prediction reliabilityML / AI methodsRank 17 Computational inference of cell states, spatial interactions and regulatorsSingle-cellRank 18 Omics methods adapted for sparse, batch-affected and long-read transcriptome dataTranscriptomicsRank 19 Tracking individual cells and protein puncta through time-lapse microscopySingle-cellRank 20 Accelerated implementations of sequencing and single-cell data processing stepsTools & infrastructure
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Rank 21 Local molecular rules generate heterogeneous population-level dynamics across systemsSystems biologyRank 22 Linkage, biophysical stability, and weak selection shape mutation fitness inferenceGenomicsRank 23 Recovering protein-level information from mixed or compositional measurementsProteomicsRank 24 Benchmarks and parameter guidance drive selection of structural analysis methodsStructural bio & protein designRank 25 Latent and manifold models extract brain complexity and dynamics from neuroimaging dataSystems biologyRank 26 Site-level mutation dynamics and wastewater sequencing track SARS-CoV-2 variant fitnessGenomicsRank 27 Molecular dynamics guides ligand design, receptor bias, and allosteric EGFR inhibitionStructural bio & protein designRank 28 Reduced mechanistic models link model structure to cell-level dynamics and dataSystems biologyRank 29 Transformers and LLMs model biological structure for perturbation and molecular bindingML / AI methodsRank 30 Software tools extend isotope flux, microbial interaction, and microbiome analysesMetabolomicsRank 31 Chromosome architecture tracks introgression and hybrid genome history across lineagesGenomicsRank 32 Generative models sample biomolecular conformations, transition paths, and energeticsStructural bio & protein designRank 33 Objective-steered generative design of proteins, peptides, and codonsStructural bio & protein designRank 34 Open tools prepare and annotate derived genomic representations for downstream analysisTools & infrastructureRank 35 Context-aware sequence representations for taxonomic classification and genome comparisonGenomicsRank 36 Non-model species genome assemblies paired with gene-level annotation and interpretationGenomicsRank 37 Metagenomic and amplicon tools validated against defined taxonomic and workflow benchmarksTools & infrastructureRank 38 Generative models augment and synthesize genomic and single-cell training dataGenomicsRank 39 Computational tools probe proteoforms, fold switching, miniproteins and molecular variantsMetabolomicsRank 40 Scalable software for k-mer hashing, pooled screening designs, and genomic intervalsTools & infrastructure