Top 40
View all ›BACKFILLED Code and industry signals are partial for backfilled days.
Rank 1
Transcriptomics
Computational models infer spatial gene regulation and pathway activity from tissue data
Spatial transcriptomics and histology now support explicit models of gene regulation, pathway activity, and RNA organization at cell resolution.
8 preprints · 2 published · ↑ 2.3× vs 4-wk avg
Rank 2 Structural bio & protein design
ML and physics-based methods advance binding affinity and docking prediction
Recent preprints and papers pair deep learning and quantum-classical methods with docking and structure benchmarks to improve binding prediction.
4 preprints · 5 published · ↑ 1.8× vs 4-wk avg
Rank 3 Transcriptomics
Computational tools integrate spatial omics layers to infer localization and expression
Recent spatial omics items address quality control, cross-platform integration, and localization inference from organelle and spatial proteomics data.
3 preprints · 5 published · ↑ 1.8× vs 4-wk avg
Rank 4 ML / AI methods
Graph and language models predict biomedical associations from sequence and structure
Recent benchmarks test pretrained genomic language models and graph predictors against task-specific methods on RNA, drug and single-cell tasks.
5 preprints · 7 published · ↑ 1.7× vs 4-wk avg
Rank 5 Systems biology
Structured low-dimensional models link multi-omic and microbiome data to phenotypes
Interpretable, structure-constrained models are being applied to heterogeneous multi-omic and microbial datasets to decode phenotypes.
4 preprints · 2 published · ↑ 1.7× vs 4-wk avg
Rank 6 Computational pipelines turn untargeted LC-MS/MS data into compound and disease readouts↑ 1.6×MetabolomicsRank 7 Graphs resolve haplotypes from ambiguous, mixed, and low-coverage sequencing reads↑ 1.6×GenomicsRank 8 Compressed indexes and sketches advance k-mer, long-read and 16S sequence analysisTools & infrastructureRank 9 New tools sharpen structural variant annotation and variant interpretation in genomicsGenomicsRank 10 Sequence context biases long-read RNA sequencing and Pol II disassociation mappingTools & infrastructureRank 11 Reliable inference for mechanistic models of stochastic and metabolic dynamicsML / AI methodsRank 12 Semi-supervised and foundation models extend to biomedical imaging and cytometryML / AI methodsRank 13 Open software tools standardise, integrate and visualise derived omics and genomic dataTools & infrastructureRank 14 Latent models link brain imaging, genotype and cognition to Alzheimer's phenotypesML / AI methodsRank 15 Telomere-to-telomere assemblies resolve gap-free dipteran and plant reference genomesGenomicsRank 16 Tunable molecular perceptrons and resource-coupled weights in genetic circuitsSystems biologyRank 17 Refining effect sizes and gene-level tests in genetic association studies with functional…GenomicsRank 18 Backbone-conditioned ssDNA design and differentiable RNA energy parameter fittingStructural bio & protein designRank 19 Whole-brain and neural mass models tested against brain criticality and oscillationsSystems biologyRank 20 Atom-level and motif-scaffolding methods now design de novo enzyme active sitesStructural bio & protein design
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Rank 21 Haplotype and crossover structure made explicit before genetic association inferenceTools & infrastructureRank 22 Generative and learned models supply training data and fill in incomplete measurementsML / AI methodsRank 23 Learned latent embeddings for microbial growth, patient trajectories and multi-omic dataML / AI methodsRank 24 Quantitative frameworks for transcriptomic states, RNA editing, and tissue spatial fieldsTranscriptomicsRank 25 Language models and benchmarks applied to single-cell and multi-omics data analysisML / AI methodsRank 26 Simulation-based benchmarking and verification of sequencing and methylation toolsTools & infrastructureRank 27 Transcript-level RNA-seq workflows reveal ancestry bias in gene annotationTranscriptomicsRank 28 Curated references and probabilistic models refine metagenomic taxonomic profilingTools & infrastructureRank 29 Simplified microbial community models are tested for failure across coupling regimesSystems biologyRank 30 Graph and contrastive learning decode cancer biomarkers and single-cell programsSingle-cellRank 31 MD methods map distal thermal pathways, ion overbinding and torsional energeticsStructural bio & protein designRank 32 Label-free imaging and scattering yield quantitative per-cell and per-particle descriptorsML / AI methodsRank 33 Privacy-preserving methods for GWAS and haplotype phasing on sensitive genomesGenomicsRank 34 Explicit objective functions now drive inference of cell types, lineages and markersSingle-cellRank 35 Exact and closed-form stochastic solutions for size-controlled growth and homeostasisSystems biologyRank 36 Wastewater sequencing enables mutation-level fitness estimates for SARS-CoV-2 variantsSystems biologyRank 37 Oxygen shapes subglacial microbes as environmental metagenomic surveys scale upTools & infrastructureRank 38 Plasmids disseminate Type VI secretion systems; genomes refine taxonomic boundsGenomicsRank 39 Curated resources and ML tools advance gene regulation and cell communication analysisTools & infrastructureRank 40 Multi-omic maps link regulatory variation to egg-laying traits, gut microbiome, and…Epigenomics