Top 40
View all ›BACKFILLED Code and industry signals are partial for backfilled days.
Rank 1
Single-cell
Learned representations and label-efficient models for single-cell imaging and omics
Imaging and single-cell omics increasingly rely on learned models, and label-efficient, self-supervised tools are emerging to reduce annotation burden.
2 preprints · 6 published · ↑ 2.3× vs 4-wk avg
Rank 2 ML / AI methods
Machine learning models predict immunogenicity of neoantigens and tumor epitopes
Recent tools pair omics-derived tumor antigen discovery with learned immunogenicity models, targeting neoepitope selection for vaccines and immunotherapy.
2 preprints · 6 published · ↑ 2.3× vs 4-wk avg
Rank 3 Tools & infrastructure
Large-scale genome and metagenome mining links sequence content to microbial traits
Expanding genome and metagenome collections now allow specific trait classes to be assigned from broad microbial sampling.
7 preprints · 1 published · ↑ 2.1× vs 4-wk avg
Rank 4 ML / AI methods
Pretrained sequence models tackle resistance, interactions and mRNA design
Recent preprints apply genomic, mRNA and protein language models to resistance, interaction and zoonotic surveillance tasks.
6 preprints · ↑ 1.9× vs 4-wk avg
Rank 5 Single-cell
Foundation and graph models for spatial and single-cell transcriptomic representations
Recent preprints pair spatial and single-cell foundation models with scrutiny of benchmark sampling biases.
9 preprints · 2 published · ↑ 1.7× vs 4-wk avg
Rank 6 Attention over biomedical graphs predicts binding, perturbation, and interaction outcomes↑ 1.6×ML / AI methodsRank 7 Simulation and modeling probe biomolecular binding and protein conformational states↑ 1.5×Structural bio & protein designRank 8 Statistical and deep learning methods for microbiome and multi-omics analysisSystems biologyRank 9 Pretrained structure and sequence models repurposed for constrained molecular designStructural bio & protein designRank 10 PLM embeddings dominate mutation stability prediction; structure adds value mainly for…ML / AI methodsRank 11 Prospective benchmarks test protein AI models on ligand binding and antibody…Structural bio & protein designRank 12 Machine learning and burden models score variant effects beyond single lociGenomicsRank 13 Faster methods for heritability, local h2, Y-haplogroup and ancestry inference from…GenomicsRank 14 Graph and deep learning models predict cancer subtypes and drug-drug interactionsML / AI methodsRank 15 Restraints and force-field tests refine peptide and RNA conformational ensemblesStructural bio & protein designRank 16 Omics tools convert platform outputs into validated, analysis-ready formsTools & infrastructureRank 17 Intrinsic noise limits timing precision and robustness in gene regulatory circuitsSystems biologyRank 18 Comparative genomics traces gene family gains, losses, and innovation across eukaryotesGenomicsRank 19 Flexible and learned scoring extend alignment to repeats and remote homologsTools & infrastructureRank 20 Haplotype-aware single-cell tools for CRISPR editing and lentiviral integration mappingTools & infrastructure
Show 18 more
Rank 21 LLMs and deep recommenders predict drug combinations and druggable disease-target linksML / AI methodsRank 22 Software redesigns speed molecular surface, electrostatics, and property predictionStructural bio & protein designRank 23 LLMs Orchestrate Retrieval and Curation Across Biomedical ResourcesML / AI methodsRank 24 Analysis tools pair computational methods with curated biological data and accessTools & infrastructureRank 25 Epigenetic state linked to locus-specific chromatin mechanics and nucleosome energeticsEpigenomicsRank 26 Learned models infer microbial biosynthesis traits from genomes and literatureML / AI methodsRank 27 Open tools released for non-canonical residues, RNA ensembles and lipid nanobubble MDTools & infrastructureRank 28 Interactive computational tools span membrane nanostructure, neuron biophysics and EMSystems biologyRank 29 Transposon enhancers and acrocentric chromosome evolution reshape genome regulationGenomicsRank 30 Models of ciliary mixing, corneal repair, EGFR signaling and epithelial migrationSystems biologyRank 31 Simulations map residue-level determinants of amyloid aggregation and its inhibitionStructural bio & protein designRank 32 Path-integral and graph models infer treatment and fitness dynamics from limited dataSystems biologyRank 33 Generative AI designs antimicrobial peptides with targeted and programmable propertiesStructural bio & protein designRank 34 Bacterial metabolic, antifungal, and protein interaction prediction modelsSystems biologyRank 35 Computational tools for stable protein design and genetically stable gene constructsTools & infrastructureRank 36 Haplotype-resolved genome assemblies tie haplotype diversity to resistance traits in…GenomicsRank 37 Physics-based and deep learning models extend RNA structure and nanopore read analysisStructural bio & protein designRank 38 Linking multimodal molecular structure to interpretable drivers and causal instrumentsSingle-cell