Week 1, 2026 · Dec 29 – Jan 4

Top 40

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Systems biology

Tissue-wide planar cell polarity emerges from local signals in cellular Potts models

ML / AI methods

Fusing sequence, structure and graph features for multimodal interaction prediction

Structural bio & protein design

Learned models expand protein conformational sampling and sequence-energy fitting

Tools & infrastructure

Benchmarks expose setting-dependent limits of learned protein-ligand binding and docking

Genomics

New callers resolve CNVs, structural variants, uniparental disomy and aneuploidy from NGS

6 DFT reference data refines torsion parameters and hybrid ML/MM simulation setupStructural bio & protein design

7 Gap-free assemblies and pangenomes expose structural variation across crop lineagesGenomics

8 Inferring kinetics and time labels from nascent, untimed, and mistimed transcriptomic dataSystems biology

9 Curated enzyme databases with HMM pipelines expand halogenase and PET-degrader discoveryTools & infrastructure

10 Language and graph foundation models target drug repurposing and molecule generationML / AI methods

11 Protonation and ion handling shape membrane transport and penetration in MD simulationsStructural bio & protein design

12 ML rescoring and mass offset search refine peptide and PTM identification from MS/MSProteomics

13 Knowledge graphs integrate metabolite, microbial, and trait data for queryable biologyTools & infrastructure

14 Curated databases pair bioactivity records with structural and mechanistic annotationTools & infrastructure

15 Mechanistic models tie exosome cargo, viscosity and ion pumping to cell-scale behaviourSystems biology

16 Physical polymer models connect 3D genome organization to regulatory outputEpigenomics

17 Software tools for batch correction, cfDNA fragment analysis and proteomics QCTools & infrastructure

18 Inhibitory integration, burst-driven weight attractors, and Φ in spiking networksSystems biology

19 Protein language models encode nativeness, taxonomy, and memorization beyond trainingML / AI methods

20 Curated databases structure microbial habitat, antigen, lysin and biosynthetic gene dataML / AI methods

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21 Browser and agent-driven tools standardize EV, transcriptomic and omics plotting workflowsTools & infrastructure

22 Stochastic variability and network structure set cellular timing and sizeSystems biology

23 LLMs grounded in curated biomedical databases for gene and literature reasoningML / AI methods

24 Computational tools map Plasmodium population genomics and recurrence inferenceTools & infrastructure

25 Automated pipelines convert raw sequence data into queryable, reusable genomic resourcesTools & infrastructure

26 Structure-aware statistical methods for single-cell and spatial transcriptomics inferenceML / AI methods

27 Learned models reshape cryo-EM reconstruction and electron microscopy acquisitionStructural bio & protein design

28 Deep models for single-cell perturbation, annotation, and foundation-model interpretationML / AI methods

29 Pretrained genomic language models are repurposed for expression and variant predictionML / AI methods

30 Atlases and tools link GWAS loci and QTLs to cell types, pathways, and mechanismsGenomics

31 Sequence patterning governs peptide condensation and membrane translocationStructural bio & protein design

32 Spectral libraries and origin-aware annotation advance LC-MS metabolomicsMetabolomics

33 Repeats and chromatin context shape genome architecture and regulatory variationEpigenomics

34 AI structure models extended to protein conformational dynamics and ensemble samplingStructural bio & protein design

35 Learned multi-omics integration spans single-cell clustering and patient survivalSingle-cell

36 Cryo-EM and cryo-ET density guides generative and regression models of atomic structureStructural bio & protein design

37 Genome-scale constraint maps proto-gene precursors and duplicate-gene divergenceGenomics

38 Inferring temporal cell-state dynamics from snapshot single-cell and spatial dataSingle-cell

39 Tissue-resolved metabolic models, spatial lipidomics, and curated MASH transcriptomicsMetabolomics

40 Spatial statistics and dimension reduction resolve molecular patterns in omics dataProteomics

Week 1, 2026 · Dec 29 – Jan 4

Top 40

Tissue-wide planar cell polarity emerges from local signals in cellular Potts models

Fusing sequence, structure and graph features for multimodal interaction prediction

Learned models expand protein conformational sampling and sequence-energy fitting

Benchmarks expose setting-dependent limits of learned protein-ligand binding and docking

New callers resolve CNVs, structural variants, uniparental disomy and aneuploidy from NGS

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