Week 4, 2026 · Jan 19 – Jan 25

Top 40

ML / AI methods

Generative models steer biomolecular design via alignment, energy biasing, and sampling

Genomics

Alignment-free k-mer features resolve variant and class differences in genomic sequences

Single-cell

LLM agents grounded in raw single-cell data for annotation and perturbation prediction

Genomics

Genome-scale constraint maps proto-gene precursors and duplicate-gene divergence

Genomics

Transfer, kernel and penalized methods raise power in genetic association studies

6 Generative design of biomolecules and molecules paired with explicit feasibility scoringStructural bio & protein design

7 Deep models for single-cell perturbation, annotation, and foundation-model interpretationML / AI methods

8 Graph representations of genetic variation scale across ARG, genotyping, and simulationTools & infrastructure

9 Structure-aware statistical methods for single-cell and spatial transcriptomics inferenceML / AI methods

10 Somatic variants joined to dependency and single-cell context for target nominationML / AI methods

11 Single-cell and population variability is used to infer aging and neurogenic mechanismsSingle-cell

12 Structure-aware architectures couple molecular substructures with biological networksML / AI methods

13 Latent diffusion models extend to histology staining and drug-response predictionML / AI methods

14 Protein language models and LLMs predict mutation, editability and PAM specificityML / AI methods

15 AI structure models extended to protein conformational dynamics and ensemble samplingStructural bio & protein design

16 Protonation and ion handling shape membrane transport and penetration in MD simulationsStructural bio & protein design

17 Software tools for batch correction, cfDNA fragment analysis and proteomics QCTools & infrastructure

18 Knowledge graphs integrate metabolite, microbial, and trait data for queryable biologyTools & infrastructure

19 Chromosome-scale and pangenome assemblies advance fungal and polyploid crop genomicsGenomics

20 Open deep learning pipelines extract plant root, fruit, and growth traits from imagesTools & infrastructure

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21 Scalable tools refine orthology and gene histories across diverse genome collectionsGenomics

22 Sequence patterning governs peptide condensation and membrane translocationStructural bio & protein design

23 Browser and agent-driven tools standardize EV, transcriptomic and omics plotting workflowsTools & infrastructure

24 LLM agents orchestrate omics tools and models through multi-step, validated workflowsML / AI methods

25 New callers resolve CNVs, structural variants, uniparental disomy and aneuploidy from NGSGenomics

26 Cryo-EM and cryo-ET density guides generative and regression models of atomic structureStructural bio & protein design

27 Inhibitory integration, burst-driven weight attractors, and Φ in spiking networksSystems biology

28 Physical polymer models connect 3D genome organization to regulatory outputEpigenomics

29 Repeats and chromatin context shape genome architecture and regulatory variationEpigenomics

30 Spatial statistics and dimension reduction resolve molecular patterns in omics dataProteomics

31 Inferring temporal cell-state dynamics from snapshot single-cell and spatial dataSingle-cell

32 Genomic language models are being interrogated for regulatory and biological structureGenomics

33 Automated curation and standardization of small-molecule data for predictive modelingTools & infrastructure

34 Neural and hybrid models infer population history from LD, ARGs, and mtDNA distancesGenomics

35 Learned models encode fragment topology and bond-edit search for molecular structureMetabolomics

36 Deep learning automates particle picking, fusion, and event detection in microscopyStructural bio & protein design

37 Local LLMs and modular frameworks standardize single-cell metadata, model use and…Single-cell

38 Curated knowledge bases convert literature into queryable biomedical evidenceTools & infrastructure

39 Tissue-wide planar cell polarity emerges from local signals in cellular Potts modelsSystems biology

40 Rna Regulation Mapping Methods (auto label)Transcriptomics

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