Top 40
View all ›BACKFILLED Code and industry signals are partial for backfilled days.
Rank 1
Tools & infrastructure
Curated databases integrate single-cell and spatial transcriptomics across platforms
Spatial platforms now span Visium, Xenium, MERFISH and Stereo-seq, motivating cross-platform harmonization within curated resources.
3 preprints · 8 published · 1 tool · ↑ 4.0× vs 4-wk avg
Rank 2 Single-cell
Learned and mechanistic models infer single-cell state dynamics from lineage context
Recent preprints and publications pair single-cell dynamical models with lineage tracing, gene regulatory networks, and biological constraints.
10 preprints · 2 published · ↑ 3.0× vs 4-wk avg
Rank 3 Single-cell
Normalization and spatial testing sharpen single-cell and spatial expression readouts
Recent preprints and publications apply new normalization, probe-based spatial mapping and joint spatial testing to single-cell and spatial transcriptomes.
8 preprints · 3 published · ↑ 2.7× vs 4-wk avg
Rank 4 Tools & infrastructure
Curated structure and affinity databases are benchmarking folding and pose predictors
Recent releases add benchmark-ready splits, paired apo-holo states, and condition-resolved affinities to structure-based predictor evaluation.
2 preprints · 6 published · ↑ 2.0× vs 4-wk avg
Rank 5 Genomics
Genetic variants and tandem repeats reshape cell-type gene regulation
Population-scale single-cell QTL maps now link variants and repeats to cell-type chromatin accessibility and expression.
4 preprints · 4 published · ↑ 2.0× vs 4-wk avg
Rank 6 Generative models design full-length antibodies and binders across hard targets↑ 1.8×Structural bio & protein designRank 7 Split design and perturbation benchmarks reshape validity claims for single-cell models↑ 1.8×ML / AI methodsRank 8 Conditioned ML models predict protein interactions, peptides, hotspots, and stability↑ 1.9×ML / AI methodsRank 9 Read-level methylation models and jagged-end correction refine cell-free DNA profiling↑ 1.8×EpigenomicsRank 10 LLM agents with executable checks and provenance tracking for proteomics and taxonomy↑ 1.6×Tools & infrastructureRank 11 Modeling interaction-induced conformational change across protein complexes↑ 1.6×Structural bio & protein designRank 12 Knowledgebases unify bacterial genomes, arthropod and digester microbiomes↑ 1.6×Tools & infrastructureRank 13 Resources linking GWAS variants to regulatory function and cell-type-resolved effects↑ 1.5×Tools & infrastructureRank 14 Linking genomic variation to function and selection across genomes and scalesGenomicsRank 15 Predicting gene expression from H&E histology via residual and graph modelsTranscriptomicsRank 16 Model-Based Biological Quantities from Single-Timepoint and Non-Contrast Brain Imaging↑ 1.6×ML / AI methodsRank 17 Interpretable models expose folding, concept, and rewiring structure in biology↑ 1.5×ML / AI methodsRank 18 LLM agents constrained by explicit evidence sources for biomedical analysisML / AI methodsRank 19 Learned models prioritize protein variants and residues with calibrated uncertaintyStructural bio & protein designRank 20 Fused protein language model embeddings predict enzyme, variant, and kinase propertiesML / AI methods
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Rank 21 Training data form and augmentation control performance in low-data molecular generationML / AI methodsRank 22 Software unifies design and assessment of hybrid capture and oligo pool reagentsTools & infrastructureRank 23 Single-molecule footprinting frameworks map chromatin states and co-accessibilityEpigenomicsRank 24 Spatially resolved models couple transport, diffusion, and geometry across scalesSystems biologyRank 25 Pretrained genomic models adapted to cell-type and individual-level regulatory readoutsGenomicsRank 26 Reference-controlled simulations probing RNA ensembles and helicase unwinding mechanismsStructural bio & protein designRank 27 Simulations link non-equilibrium driving to condensate and chromatin phase organizationStructural bio & protein designRank 28 Chromosome-scale assemblies expose compartmentalized and nitrogen-fixing organelle genomesGenomicsRank 29 Imbalance handling, active learning and model family in ADMET and hERG regressionML / AI methodsRank 30 Bifurcation structure of neuronal and network models: degeneracy, delays, and burstingSystems biologyRank 31 Subgroup-aware regression and selection scores localize programs in scRNA-seq dataSingle-cellRank 32 MD simulations and HDX-MS jointly resolve protein conformational dynamicsStructural bio & protein designRank 33 Updated curated databases expand enhancer, lncRNA, and rice expression evidenceTools & infrastructureRank 34 Benchmarked transcript quantification and isoform tools with internal self-validationTranscriptomicsRank 35 Queryable, source-linked knowledgebases integrating clinical and molecular evidence in…Tools & infrastructureRank 36 Constraint-based robustness and GPR-aware gene deletion ranking for microbial metabolismSystems biologyRank 37 Genome-wide and complex I models extend mitochondrial DNA variant pathogenicity scoringGenomicsRank 38 Predicted protein structures feed curated resources and surface-level screensStructural bio & protein designRank 39 Reduced dynamical models convert treatment failure into dosing and relapse predictionsSystems biologyRank 40 Integrated reporting and reference choice reshape computational variant interpretationGenomics