#2 · ML / AI methods
Interpretability Tools Recover Known Visual Selectivity in Neural Models
The dominant thread is validation of machine learning models of neural activity against established neurophysiology. Two items build or benchmark models of neural data directly: a spatiotemporal TDANN with contrastive training reproduces macaque MT direction maps and pinwheel structure, and SpikeProphecy provides a causal autoregressive benchmark for spike-count forecasting across 105 Neuropixels sessions. Other items probe trained encoders or foundation models with attribution and visualization methods. Feature visualization recovers the V1-V4 hierarchy and FFA, MT, and PPA selectivity in TRIBE v2; mechanistic analysis localizes image features driving human visual cortex voxels with causal validation; and LRP on EEG transformers exposes ocular shortcuts in motor imagery alongside a central arousal signature. What is new is the use of these checks as discovery tools, including a closed-loop framework that converts digital-twin models of macaque V1 and V4 neurons into verifiable language descriptions of selectivity.
Published papers
Early vs late fusion of qMIDS with machine learning based classifiers for oral cancer diagnosis from gene expression data.
Late fusion of qMIDS with ML classifiers beats early fusion for oral cancer diagnosis from expression data; robust across cohorts.
Preprints
Comparison of anomaly detection and supervised learning for acute myeloid leukemia blast identification: A proof-of-concept study
Compares anomaly detectors, Random Forest and UMAP-HDBSCAN for AML blast flow cytometry; Random Forest validates best.
Evaluation design shapes estimates of cross-donor generalization in single-cell classification of cell-type
Random cell splits inflate single-cell classifier F1 over donor-held-out evaluation; bias depends on the classification regime.
Evaluation of Cross-slice Imputation for Spatial Proteomics
Benchmarks learning-based and alignment-based methods for cross-slice protein imputation in spatial single-cell proteomics; learning methods outperform…
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