Top 40
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Structural bio & protein design
Probing data and learned models resolve RNA structure and ligand-binding sites
Chemical probing data and AlphaFold-predicted RNA structures are now paired with learned models for structure and binding-site prediction.
Tools & infrastructure
Integrative resources and models for regulatory genomics and phenotype prediction
Multi-omics resources and deep generative or Bayesian models are now being applied to enhancers, regulatory networks, senescence and kinases.
Single-cell
Integrating spatial and single-cell transcriptomics with systematic method evaluation
New spatial and single-cell tools now appear alongside formal evaluation, including a seven-tool ambient RNA decontamination benchmark.
Genomics
K-mer and phylogenomic tools advance genome-level classification and comparison
Recent releases and preprints extend k-mer and maximum-likelihood tools to fungal taxonomy, viral phylogenies, and bacterial genome analysis.
Genomics
Haplotype-aware variant calling extends to single-cell and cancer genomes
Recent work extends germline and somatic variant attribution to single-cell modalities, parental haplotypes, and complex loci.