Week 21, 2026 · May 18 – May 24

Top 40

Genomics

Integrating diverse variant and annotation data to improve genetic risk prediction

Genomics

Models infer microbial and viral traits from large genomic and metagenomic datasets

Tools & infrastructure

Learned models link histology and spatial transcriptomics to predict expression and niches

Systems biology

Design-aware statistical models for differential analysis of omics and imaging data

Genomics

Comparative genomics partitions duplication, transfer and synteny across lineages

6 MD and cofolding models probe conformational states in kinases, Aβ, and HIV-1 EnvStructural bio & protein design

7 Correcting RNA degradation and hashtag demultiplexing in single-cell transcriptomicsSystems biology

8 Learned multimodal and graph representations for protein and RNA predictionML / AI methods

9 Pretrained generative models extend to fMRI forecasting, diagnosis, and imagerySystems biology

10 Learned predictors score protein interactions, variant effects, and peptide activityML / AI methods

11 MD ensembles and replica-exchange sampling map folding and binding pathwaysStructural bio & protein design

12 Benchmark baselines and transfer conditions reshape reported gains in biological MLML / AI methods

13 Computational models link germinal center B cell states to antibody affinity maturationGenomics

14 Constraints and cross-feeding shape inferred metabolic fluxes and microbial nichesSystems biology

15 Benchmarks and learned models expose gaps in metagenomic analysis softwareML / AI methods

16 Reproducible environments, DNA library design and standard formats for biology toolsStructural bio & protein design

17 Interpretability Tools Recover Known Visual Selectivity in Neural ModelsML / AI methods

18 LLM agents and multimodal models convert literature and spectra into molecular knowledgeTools & infrastructure

19 Simulation methods extend to cyclic peptides, non-canonical residues and polypeptoidsStructural bio & protein design

20 Deep learning automates microscopy and histology image analysis with less labelled dataML / AI methods

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21 Generative models map mass spectra directly to candidate molecular structuresML / AI methods

22 Updated tools for microbial pangenomics, plasmid recovery and phylogenetic inferenceSystems biology

23 Spatial models couple influenza dispersal, defective particles and interferon signallingML / AI methods

24 Internal ground truths benchmark RNA-seq transcript and expression inference toolsGenomics

25 Mechanistic models link cell-scale rules to invasion, containment and therapy outcomesSystems biology

26 Multi-omic and structural data are converted into drug and target prioritization outputsGenomics

27 Graph neural networks model molecular interactions, drug synergy and disease driversSystems biology

28 Graph storage and streaming parsers reshape population-scale variant computationTools & infrastructure

29 Bifurcation structure and heterogeneity determine persistence beyond threshold indicesSystems biology

30 Chromatin structure and nucleosome states inferred from sequencing and contact mapsStructural bio & protein design

31 MD simulations link conformational states to membrane binding and organizationStructural bio & protein design

32 Chromosome-level assemblies link genome gigantism and gene loss to lineage evolutionGenomics

33 Free energy and coarse-grained physics methods for biomolecular binding and interfacesStructural bio & protein design

34 New tools speed variant annotation, GWAS, and epigenomic and cytometry analysisTools & infrastructure

35 Benchmarks probe AlphaFold model accuracy across peptides, RNA, and antibody complexesStructural bio & protein design

36 Benchmarks and packaged pipelines standardize omics analysis toolsTools & infrastructure

37 Reproducible tools for assessing and streamlining omics data analysis workflowsTools & infrastructure

38 Isoform-resolved single-cell and single-molecule methods quantify transcript variantsEpigenomics

39 New tools for recombination, metagenomic decontamination, and microbial community designTools & infrastructure

40 Refined inference of tumor methylation, structural variants and clonal structureSingle-cell