TrendBio

#4 · Genomics

Comparative genomics partitions duplication, transfer and synteny across lineages

4 preprints · 2 published
Items per day, last 8 weekstoday: 6

The common thread is the use of high-quality genome sequences as the substrate for comparative inference about genome architecture. The Asgard archaea phylogenomic study explicitly partitions genome expansion, attributing it mainly to gene duplication rather than horizontal transfer, with transfers concentrated in peripheral metabolic genes. The Palythoa assemblies, described as new high-quality genomes from an early divergent hexacorallian, enable comparison of symbiosis genes and bacterial polyketide synthases linked to palytoxin. Synolog supplies the methodological layer: a scalable, benchmarked synteny framework that identifies orthologs, synteny clusters, retrogenes and segmental duplications across genomes. What is new is the explicit duplication-versus-transfer partitioning in an archaeal lineage, paired with a scalable tool for characterizing genome architecture. The items are heterogeneous in scope, so the shared element is methodological rather than a common biological finding.

Published papers

Preprints

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