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BACKFILLED Code and industry signals are partial for backfilled days.

Rank 1

Single-cell

Geometry-aware models infer cell dynamics and spatial organization from single-cell data

Geometry-aware representation and flow-matching methods are being applied to spatial, trajectory, and time-lapse single-cell data.

6 preprints · ↑ 1.8× vs 4-wk avg
Rank 2

ML / AI methods

Learned latent-space models predict perturbation and drug response from multi-omics data

A new out-of-distribution benchmark of 20 perturbation models on Perturb-seq data tests generalization beyond training distributions.

9 preprints · 2 published · ↑ 1.6× vs 4-wk avg
Rank 3

Tools & infrastructure

Single-cell and spatial atlases link cell niches and communication to disease outcomes

Integrated atlases now combine single-cell, spatial, and bulk survival data to prioritize cell interactions and niches in human tissues and cancers.

4 preprints · 2 published · ↑ 1.6× vs 4-wk avg
Rank 4

Tools & infrastructure

Integrative omics pipelines and resources for reproducible multi-dataset analysis

Public single-cell, bulk, proteomic and variant datasets are being reanalysed with standardized, shareable pipelines and curated resources.

6 preprints · 4 published · ↑ 1.6× vs 4-wk avg
Rank 5

Genomics

Chromosome-scale assemblies enable repeat, transcript and cross-species gene comparisons

Haplotype-resolved and chromosome-level references now serve as explicit targets for TE expression, transcript evidence, and pangenome comparison.

6 preprints · 1 published · ↑ 1.7× vs 4-wk avg