Week 20, 2026 · May 11 – May 17

Top 40

Tools & infrastructure

Learned models link histology and spatial transcriptomics to predict expression and niches

ML / AI methods

Physical and quantum-derived references inform learned models of molecular properties

ML / AI methods

Learned predictors score protein interactions, variant effects, and peptide activity

ML / AI methods

Sequence- and structure-based models predict protein function and dynamics

Structural bio & protein design

Graph and language-model encoders advance drug-target and synergy prediction

6 Regional brain organization metrics test normative models, criticality, and morphometrySystems biology

7 Correcting RNA degradation and hashtag demultiplexing in single-cell transcriptomicsSystems biology

8 New tools speed variant annotation, GWAS, and epigenomic and cytometry analysisTools & infrastructure

9 Computational models link germinal center B cell states to antibody affinity maturationGenomics

10 Graph and attention models fuse spatial and single-cell multi-omics dataML / AI methods

11 Protein language model embeddings enable sequence-based prediction of protein traitsML / AI methods

12 Mechanistic models link cell-scale rules to invasion, containment and therapy outcomesSystems biology

13 Multi-omic and structural data are converted into drug and target prioritization outputsGenomics

14 Pretrained generative models extend to fMRI forecasting, diagnosis, and imagerySystems biology

15 Computational models link genetic variants to RNA binding and cell-type expressionTools & infrastructure

16 Learned latents steer protein conformations and encode evolutionary structureML / AI methods

17 Graph neural networks model molecular interactions, drug synergy and disease driversSystems biology

18 Reproducible tools for assessing and streamlining omics data analysis workflowsTools & infrastructure

19 Models link non-genetic B cell state dynamics to antibody affinity maturationSystems biology

20 Machine learning maps tissue and molecular profiles to cancer outcomes and subtypesML / AI methods

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21 Interpretability Tools Recover Known Visual Selectivity in Neural ModelsML / AI methods

22 Noise-driven dynamics shape neuronal firing, calcium states, and gait fluctuationsSystems biology

23 Adhesion, noise, and discretization shape collective and single-cell migration modelsSystems biology

24 Benchmarks and packaged pipelines standardize omics analysis toolsTools & infrastructure

25 Integrating diverse variant and annotation data to improve genetic risk predictionGenomics

26 Transformer and deep learning tools benchmarked against established genomics methodsGenomics

27 Free energy and coarse-grained physics methods for biomolecular binding and interfacesStructural bio & protein design

28 Internal ground truths benchmark RNA-seq transcript and expression inference toolsGenomics

29 MD ensembles and replica-exchange sampling map folding and binding pathwaysStructural bio & protein design

30 Chromatin structure and nucleosome states inferred from sequencing and contact mapsStructural bio & protein design

31 Generative models steered by RL, fragments, and SMARTS for molecule and linker designStructural bio & protein design

32 MD simulations link conformational states to membrane binding and organizationStructural bio & protein design

33 Sequencing and inference methods resolve nucleic acid sequence, structure, and usageGenomics

34 Chromosome-level assemblies link genome gigantism and gene loss to lineage evolutionGenomics

35 LLM agents and multimodal models convert literature and spectra into molecular knowledgeTools & infrastructure

36 Reproducible environments, DNA library design and standard formats for biology toolsStructural bio & protein design

37 New tools for recombination, metagenomic decontamination, and microbial community designTools & infrastructure

38 Benchmarks probe AlphaFold model accuracy across peptides, RNA, and antibody complexesStructural bio & protein design

39 Isoform-resolved single-cell and single-molecule methods quantify transcript variantsEpigenomics

40 Encoding spatial and relational structure in high-dimensional omics analysisSingle-cell