Top 40
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Rank 1
Single-cell
Joint histology, spatial and single-cell data correct and extend tissue transcriptomics
Multimodal tissue methods now reconstruct and align spatial and single-cell transcriptomes using histology and atlas references.
8 preprints · 3 published · ↑ 3.5× vs 4-wk avg
Rank 2 ML / AI methods
Generative models of omics data tested for robustness to noise and hidden variability
Recent single-cell and multi-omics preprints and publications assess predictive models by robustness to missing inputs, outliers and latent variability.
9 preprints · 4 published · ↑ 2.2× vs 4-wk avg
Rank 3 Structural bio & protein design
Computational pipelines span target evidence, spectra, and molecular dataset curation
Recent items pair literature-scale evidence mining with benchmarking and deep models for target validation and molecule annotation.
2 preprints · 4 published · ↑ 1.8× vs 4-wk avg
Rank 4 Genomics
STR variation and haplotype-resolved assemblies refine population and variant inference
Denser variant representations, from genome-wide STRs to haplotype-resolved assemblies, now extend ancestry and structural variant inference.
3 preprints · 2 published · ↑ 1.8× vs 4-wk avg
Rank 5 Structural bio & protein design
Flexible and disordered protein predictions tested against experimental observables
Recent preprints pair measured binding and SAXS data with benchmarks of AI cofolding and ensemble methods for disordered and flexible proteins.
5 preprints · 1 published · ↑ 1.6× vs 4-wk avg
Rank 6 Learned models infer regulatory context from RNA, DNA, and epigenomic inputs↑ 1.6×ML / AI methodsRank 7 Protein language models and 3D graph learning are applied to peptide design and prediction↑ 1.6×ML / AI methodsRank 8 External reference data constrain structural model refinement and assessment↑ 1.6×Structural bio & protein designRank 9 Read-level tools assign taxa and parse rDNA and ITS regions from sequencing dataGenomicsRank 10 Transformer embeddings are tested for which biological structure they actually encode↑ 1.6×ML / AI methodsRank 11 Sequence models targeting unseen labels, splice annotation, and mutation pathogenicityML / AI methodsRank 12 Sequencing frameworks map tRNA structure, modification, and RBP-RNA bindingTranscriptomicsRank 13 Statistical frameworks for batch, phylogeny, and uncertainty in omics inferenceTools & infrastructureRank 14 Learned models target input design for single-cell and genome-scale regulationSingle-cellRank 15 Graph and multi-omics models predict drug-target and clinical outcomesML / AI methodsRank 16 Multi-evidence scoring maps proteome motifs, complexes, and secretome folds across taxaGenomicsRank 17 Learned models guide design of AAV capsids, mRNA lipid carriers, and drug pharmacokineticsML / AI methodsRank 18 Pangenomes and long-read assemblies link structural variants to crop traitsGenomicsRank 19 Force transmission across scales governs confluent tissue and epithelial mechanicsSystems biologyRank 20 Pipelines quantify individual molecular states from noisy single-molecule measurementsStructural bio & protein design
Show 17 more
Rank 21 Synaptic tuning and efficiency bound what neural decoders and spiking networks can extractSystems biologyRank 22 Protein and codon language models analyzed for internal mechanisms and inferenceML / AI methodsRank 23 Multi-omics and Mendelian randomization nominate MASLD liver genesStructural bio & protein designRank 24 Spatial entropy, mobility networks and genetic maps quantify structured dependenceGenomicsRank 25 Alignment-free k-mer models classify viral and bacterial genomes from sequence contentGenomicsRank 26 Computational strategies expand peptide and proteoform identification from MS dataProteomicsRank 27 Models link protein binding and chromatin states to 3D genome organizationEpigenomicsRank 28 Mechanistic and data-driven models recover adaptation and morphogenetic dynamicsSystems biologyRank 29 Computational models predict ligand binding and refine macromolecular ensemble accuracyStructural bio & protein designRank 30 Structural constraints and mutation probes test protein and antibody sequence modelsStructural bio & protein designRank 31 Methylation mapping and radiation-induced genome instability in human genomesEpigenomicsRank 32 Transcriptomic identity of single cells is encoded diffusely across tissue-level axesSingle-cellRank 33 Testing structure prediction and ML potentials against experimental referencesStructural bio & protein designRank 34 Computational Inference of Signaling and Proteolytic Networks from ProteomicsProteomicsRank 35 Learned models map candidate loci and shared liability from genotypes and imagingGenomicsRank 36 Simulation and workflow tools for viral, sequencing read, and selection analysesTools & infrastructureRank 37 Single-cell and latent RNA features sharpen gene regulatory and trait inferenceSingle-cell