Week 18, 2026 · Apr 27 – May 3

Top 40

Epigenomics

Benchmarks and tools expose technical biases in sequencing-based genomic assays

ML / AI methods

Benchmarks for AI virtual cell models are being tested for scientific validity

ML / AI methods

Graph and attention models fuse spatial and single-cell multi-omics data

Genomics

Sequencing and inference methods resolve nucleic acid sequence, structure, and usage

Genomics

Ancient and phased human genomes test selection and imputation inference methods

6 Cross-cohort tests expose limits of EEG, vocal, and transcriptomic biomarkersML / AI methods

7 Free energy and coarse-grained physics methods for biomolecular binding and interfacesStructural bio & protein design

8 Spatial and single-cell models infer multicellular motifs, regulators and disease linksSingle-cell

9 Isoform-resolved single-cell and single-molecule methods quantify transcript variantsEpigenomics

10 Protein language model embeddings enable sequence-based prediction of protein traitsML / AI methods

11 Regional brain organization metrics test normative models, criticality, and morphometrySystems biology

12 Generative models steered by RL, fragments, and SMARTS for molecule and linker designStructural bio & protein design

13 Fitted mechanistic models link single-cell and patient omics to regulatory dynamicsML / AI methods

14 Reproducible tools for assessing and streamlining omics data analysis workflowsTools & infrastructure

15 Biological priors make multi-omics deep learning interpretableML / AI methods

16 Computational models link genetic variants to RNA binding and cell-type expressionTools & infrastructure

17 Internal ground truths benchmark RNA-seq transcript and expression inference toolsGenomics

18 Multi-omic and structural data are converted into drug and target prioritization outputsGenomics

19 Models infer microbial and viral traits from large genomic and metagenomic datasetsGenomics

20 Chromosome-level assemblies link genome gigantism and gene loss to lineage evolutionGenomics

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21 New tools for recombination, metagenomic decontamination, and microbial community designTools & infrastructure

22 Transformer and deep learning tools benchmarked against established genomics methodsGenomics

23 Mechanistic models link cell-scale rules to invasion, containment and therapy outcomesSystems biology

24 Learned latents steer protein conformations and encode evolutionary structureML / AI methods

25 Benchmarks and packaged pipelines standardize omics analysis toolsTools & infrastructure

26 LLM agents and multimodal models convert literature and spectra into molecular knowledgeTools & infrastructure

27 Integrating diverse variant and annotation data to improve genetic risk predictionGenomics

28 Correcting RNA degradation and hashtag demultiplexing in single-cell transcriptomicsSystems biology

29 Graph and transformer models infer regulatory networks and disease-linked RNAsML / AI methods

30 Graph and language-model encoders advance drug-target and synergy predictionStructural bio & protein design

31 Simulation methods extend to cyclic peptides, non-canonical residues and polypeptoidsStructural bio & protein design

32 Encoding spatial and relational structure in high-dimensional omics analysisSingle-cell

33 New tools speed variant annotation, GWAS, and epigenomic and cytometry analysisTools & infrastructure

34 Reduced recurrent models reproduce complex dynamics across neural and molecular systemsSystems biology

35 Chromatin structure and nucleosome states inferred from sequencing and contact mapsStructural bio & protein design

36 Bifurcation structure and heterogeneity determine persistence beyond threshold indicesSystems biology

37 MD and cofolding models probe conformational states in kinases, Aβ, and HIV-1 EnvStructural bio & protein design

38 Noise, feedback and network structure shape emergent states in biological modelsSystems biology

39 MD simulations link conformational states to membrane binding and organizationStructural bio & protein design

40 Constraints and cross-feeding shape inferred metabolic fluxes and microbial nichesSystems biology