Top 40
View all ›BACKFILLED Code and industry signals are partial for backfilled days.
Rank 1
Structural bio & protein design
Learned protein models gain generalization from physical and structural priors
Recent preprints and publications test whether protein deep learning extrapolates beyond training data when physics or structural priors are added.
4 preprints · 3 published · ↑ 2.2× vs 4-wk avg
Rank 2 Tools & infrastructure
Computational tools quantify CRISPR off-target effects in screens and library design
Recent workflows target seed-driven CRISPRi off-target repression in Perturb-seq, and new knockout libraries weigh on-target against off-target activity.
1 preprint · 3 published · ↑ 1.9× vs 4-wk avg
Rank 3 Single-cell
Whole-body and organ-scale 3D maps resolve cell identity within intact tissue
Whole-mouse and whole-brain spatial atlases now reach cell-type resolution in intact 3D tissue, paired with network analysis tools.
1 preprint · 2 published · ↑ 2.0× vs 4-wk avg
Rank 4 Single-cell
Isoform-resolved quantification and annotation extend single-cell and long-read analyses
Long-read assemblies and reference-agnostic annotation now test isoform-level associations against GENCODE and alternative annotation resources.
7 preprints · 3 published · ↑ 1.8× vs 4-wk avg
Rank 5 Single-cell
Topology-aware inference of networks and pathways from omics measurements
Recent preprints and papers embed network topology, pathway priors, or copy-number structure directly into omics-based inference steps.
5 preprints · 2 published · ↑ 1.8× vs 4-wk avg
Rank 6 Graph and causal models infer gene interactions and disease links from omics data↑ 1.8×ML / AI methodsRank 7 Learned sequence and graph embeddings drive biomolecular interaction prediction↑ 1.6×ML / AI methodsRank 8 Federated and configurable software makes rare-disease variant analysis reproducible↑ 1.6×Tools & infrastructureRank 9 Spatial omics inference models now encode tissue geometry within the inference stepSingle-cellRank 10 Models link tumor cell states, spatial context, and treatment responseML / AI methodsRank 11 Sequence typing of bacterial and mycobacterial pathogens from WGS and nanopore readsTools & infrastructureRank 12 Benchmarks expose how annotation and scoring choices shift downstream genetic inferenceGenomicsRank 13 Pretrained protein language model embeddings drive peptide and protein-ligand predictionStructural bio & protein designRank 14 Generative models for DNA and molecules: reward tuning, data poisoning, reproducibilityML / AI methodsRank 15 AlphaFold models extend to proteome-scale homo- and heterodimer structuresStructural bio & protein designRank 16 Long-read metagenomics recovers uncharacterized microbial and viral genomesGenomicsRank 17 Drug-combination proteome stability profiling and benchmark reanalysis in MS proteomicsProteomicsRank 18 Automated tools chain docking, pocket extraction, and MD setup for molecular structuresStructural bio & protein designRank 19 Predictive models of biomolecular binding extend to force, proteome, and ligand contextsStructural bio & protein designRank 20 Structure and language models guide protein engineering and enzyme mining choicesStructural bio & protein design
Show 18 more
Rank 21 Chromosome-level and telomere-to-telomere assemblies for owl, marmoset, and LSDV genomesGenomicsRank 22 Inferring network connectivity from indirect neural, brain and tumor measurementsML / AI methodsRank 23 Controlled perturbations expose where phylogenetic inference becomes unreliableStructural bio & protein designRank 24 Morphological and temporal models recover single-cell dynamics from microscopy imagesSingle-cellRank 25 Modular R tools unify multi-engine glycopeptide analysis and visualizationTools & infrastructureRank 26 Repeat-resolved human genome analysis links transposable elements to chromatin statesTools & infrastructureRank 27 RL post-training enforces biological and physical validity in generative design modelsML / AI methodsRank 28 Spaced k-mers and compressed GBWT skiplists target memory-efficient sequence indexingGenomicsRank 29 Cell-type-resolved mapping of genetic variant effects on brain gene expressionGenomicsRank 30 Model-free metrics test protein ensemble quality against NMR and MD observablesStructural bio & protein designRank 31 Post-transcriptional RNA fate control: NMD escape, codon bias, poly(A) tailsGenomicsRank 32 Learned models predict genetic and clinical biomarkers from imaging and molecular dataML / AI methodsRank 33 Haplotype-resolved plant genomes expose polyploid origins and trait-linked variationGenomicsRank 34 Genome-scale diversity links Desulfovibrio strain traits to inflammatory diseaseTools & infrastructureRank 35 Open GPU tools speed nanopore basecalling; deep learning models chromatin contactsEpigenomicsRank 36 Sequence language models now predict RNA modifications and ribosome profiling coverageML / AI methodsRank 37 Joint SNP and methylation calling, and a multi-ancestry monocyte methylome atlasEpigenomicsRank 38 Inferring cell-state dynamics as distributions and paths from single-cell snapshotsSingle-cell