Week 41, 2026 · Oct 5 – Oct 11

Top 40

Structural bio & protein design

Benchmarks probe AlphaFold model accuracy across peptides, RNA, and antibody complexes

Systems biology

Correcting RNA degradation and hashtag demultiplexing in single-cell transcriptomics

Systems biology

Graph neural networks model molecular interactions, drug synergy and disease drivers

ML / AI methods

Learned predictors score protein interactions, variant effects, and peptide activity

ML / AI methods

Graph and transformer models infer regulatory networks and disease-linked RNAs

6 Spatial models couple influenza dispersal, defective particles and interferon signallingML / AI methods

7 Learned multimodal and graph representations for protein and RNA predictionML / AI methods

8 Noise-driven dynamics shape neuronal firing, calcium states, and gait fluctuationsSystems biology

9 Multi-omic and structural data are converted into drug and target prioritization outputsGenomics

10 Generative models map mass spectra directly to candidate molecular structuresML / AI methods

11 MD and cofolding models probe conformational states in kinases, Aβ, and HIV-1 EnvStructural bio & protein design

12 Learned latents steer protein conformations and encode evolutionary structureML / AI methods

13 Chromosome-level assemblies link genome gigantism and gene loss to lineage evolutionGenomics

14 Design-aware statistical models for differential analysis of omics and imaging dataSystems biology

15 Structure-aware language models detect resistance genes and map variant activityML / AI methods

16 Generative models steered by RL, fragments, and SMARTS for molecule and linker designStructural bio & protein design

17 Benchmarking segmentation and synthetic ground truth for 3D tissue and organoid imagingML / AI methods

18 LLM agents and multimodal models convert literature and spectra into molecular knowledgeTools & infrastructure

19 Reproducible environments, DNA library design and standard formats for biology toolsStructural bio & protein design

20 Integrating diverse variant and annotation data to improve genetic risk predictionGenomics

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21 Pretrained generative models extend to fMRI forecasting, diagnosis, and imagerySystems biology

22 Computational models link germinal center B cell states to antibody affinity maturationGenomics

23 Internal ground truths benchmark RNA-seq transcript and expression inference toolsGenomics

24 Graph and language-model encoders advance drug-target and synergy predictionStructural bio & protein design

25 Reduced recurrent models reproduce complex dynamics across neural and molecular systemsSystems biology

26 Context-aware models refine variant calling, eQTL mapping and polygenic predictionGenomics

27 New tools speed variant annotation, GWAS, and epigenomic and cytometry analysisTools & infrastructure

28 Reproducible tools for assessing and streamlining omics data analysis workflowsTools & infrastructure

29 Updated tools for microbial pangenomics, plasmid recovery and phylogenetic inferenceSystems biology

30 Benchmarks and tools expose technical biases in sequencing-based genomic assaysEpigenomics

31 Bifurcation structure and heterogeneity determine persistence beyond threshold indicesSystems biology

32 Simulation methods extend to cyclic peptides, non-canonical residues and polypeptoidsStructural bio & protein design

33 Sequencing and inference methods resolve nucleic acid sequence, structure, and usageGenomics

34 Learned models link histology and spatial transcriptomics to predict expression and nichesTools & infrastructure

35 Models infer microbial and viral traits from large genomic and metagenomic datasetsGenomics

36 MD ensembles and replica-exchange sampling map folding and binding pathwaysStructural bio & protein design

37 Graph storage and streaming parsers reshape population-scale variant computationTools & infrastructure

38 Spatial and single-cell models infer multicellular motifs, regulators and disease linksSingle-cell

39 Encoding spatial and relational structure in high-dimensional omics analysisSingle-cell

40 Simulations Link RNA Modifications to Conformation and Electronic StructureStructural bio & protein design