#25 · Tools & infrastructure
Curated biological reference databases receive 2026 infrastructure updates
The dominant thread is maintenance and extension of curated reference resources rather than new biological findings. Across the twelve published updates, recurring elements include expanded coverage, standardized reprocessing, and improved access. PaxDb v6.0 reprocesses 1639 public MS datasets from 392 species with a standardized FragPipe pipeline, and Expression Atlas reports more than 4500 studies across 67 species. Interoperability is a second theme: MetaNetX adds RDF reconciliation history and SPARQL access, UCSC introduces QuickLift cross-assembly annotation transfer, and AlphaFold DB is aligned to UniProt 2025_03. ChEBI reports full infrastructure and codebase modernization, and the Gene Ontology update adds over 1500 GO-CAM pathway models. SMART v10 and AlphaFold DB both report redesigned interfaces.
Published papers
SMART v10: three decades of the protein domain annotation resource.
SMART v10 updates the web-based protein domain annotation resource with 1300+ curated domain models, a redesigned interface, expanded genome coverage, and…
DisProt in 2026: enhancing intrinsically disordered proteins accessibility, deposition, and annotation.
DisProt (https://disprot.org/) is an open database integrating experimental evidence on intrinsically disordered proteins (IDPs), intrinsically disordered regio
FireProtDB 2.0: large-scale manually curated database of the protein stability data.
Thermostable proteins are crucial in numerous biomedical and biotechnological applications.
AlphaFold Protein Structure Database 2025: a redesigned interface and updated structural coverage.
Update of the AlphaFold Protein Structure Database aligned to UniProt 2025_03, with a redesigned entry page, interactive 3D viewer, isoform coverage, and…
ChEBI: re-engineered for a sustainable future.
ChEBI, a curated open database and ontology of biologically relevant chemical entities, has undergone a full infrastructure and codebase modernization with new…
Topic history
| Date | Rank |
|---|---|
| #25 | |
| #22 |