Top 40
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Single-cell
Histology and omics foundation models predict spatial gene expression and tissue niches
Pretraining at scale and cross-modal alignment now link H&E histology, spatial omics and single-cell references for expression prediction.
ML / AI methods
Foundation and compact models tested on unseen perturbations and frozen representations
Held-out perturbation and cell-state evaluations now test whether learned representations of transcriptional responses generalize beyond training conditions.
Single-cell
Reference-free and summary-level tools advance single-cell annotation and benchmarking
Methods now annotate, score, and benchmark single-cell and spatial data using summary statistics, text embeddings, and standardized benchmarks.
Structural bio & protein design
Calibrated models predict mutation stability effects, oligo melting and ASO activity
Evaluations now stress held-out generalization and calibrated outputs over headline accuracy across variant, stability, and oligonucleotide prediction tasks.
Genomics
Telomere-to-telomere assemblies resolve satellite arrays and duplicated genes
Recent complete genomes from macaque, zebra finch, giraffe and HG002 extend assembly into previously unresolved satellite and subtelomeric regions.