Top 40
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Single-cell
Multiomic single-cell profiling resolves regulatory and transcript architecture
Paired scRNA and scATAC profiling of aging PBMCs and a 2.5M-cell 5' scRNA-seq atlas now resolve TF networks and transcript-level age changes.
Single-cell
Joint batch correction and imputation for sparse single-cell and bulk proteomics
Recent proteomics methods model batch effects and missing values within a single framework rather than as sequential preprocessing steps.
Genomics
Sequence-based inference of viral fitness, host tropism, and immune escape
Protein language models and phylogenetic methods now quantify viral fitness, host range, and HLA-restricted escape from sequence data alone.
Epigenomics
Deep models map DNA sequence and chromatin accessibility to enhancer and gene control
Sequence-based models are increasingly validated against CRISPR and MPRA data across cell types and disease states.
Structural bio & protein design
Simulation and graph learning map conformational routes in proteins and complexes
Recent preprints and one publication pair MD, Markov models, and learned restraints to link protein dynamics with function and disease mutations.