Top 40
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Single-cell
Single-cell and repeat-aware methods resolve regulatory layers from RNA and chromatin data
New methods quantify repeats, isoforms, and chromatin-linked programs at finer resolution, with benchmarks probing reliability and failure modes.
ML / AI methods
AI models link tissue histology and spatial profiles to clinical outcomes
Open precomputed tumor microenvironment resources and interpretable models now allow tissue-level features to be tested against clinical endpoints.
Structural bio & protein design
Diffusion and language models steer molecular generation toward structural goals
Recent papers pair condition-aware diffusion and LLM generators with RL steering for shape- and pocket-constrained molecular design.
Genomics
Long-read and assembly tools expose hidden variation in repeats, mtDNA, and Y chromosomes
Long-read sequencing and assembly methods now resolve repeat, mitochondrial, and population-level variation that reference-based pipelines leave unresolved.
Single-cell
Single-cell atlases map genetic risk and cell-type programs across human tissues
Harmonized human single-cell atlases now enable cell-type-resolved analyses of genetic risk, sex effects, and neural maturation.