#29 · Systems biology
Host diversion and spillover risk shape arbovirus and pandemic transmission modeling
The dominant thread is quantitative modeling that converts epidemiological or experimental data into parameters and bounds relevant to surveillance and control. A published vectorial capacity framework separates reservoir and dead-end hosts, quantifying vector diversion for West Nile virus in Culex pipiens under vector control. A further published study uses experimental transmission data to quantify viral pandemic potential for spillover surveillance. A preprint applies a reusable Wright-Fisher-based model with negative frequency-dependent selection on the accessory genome to pneumococcal vaccine replacement and surveillance design. Items differ in scope, so this thread is not shared uniformly across entries. What is new is explicit treatment of host diversion as a modifier of arbovirus transmission under control, alongside models that frame surveillance strategy around selection and transmission potential.
Published papers
Quantifying vector diversion effects in zoonotic systems: A modelling framework for arbovirus transmission between reservoir and dead-end hosts.
Modelling framework for vectorial capacity with reservoir and dead-end hosts; West Nile virus in Culex pipiens under vector control.
Quantifying viral pandemic potential from experimental transmission studies.
In an effort to avert future pandemics, surveillance studies aim to identify animal viruses at high risk of spilling over into humans.
Preprints
A reusable model of pangenome selection informs optimal surveillance strategies over vaccine introductions
Reusable Wright-Fisher-based model with negative frequency-dependent selection on accessory genome explains pneumococcal vaccine replacement and guides…
Topic history
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| #29 | |
| #27 | |
| #26 | |
| #32 |