Top 40
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Single-cell
Single-cell and spatial transcriptomics tools resolve niche-dependent gene co-expression
Expanding spatial and single-cell datasets demand context-aware methods and curated resources for regulatory inference.
Genomics
Variant effects on expression and chromatin resolved at single-cell and haplotype scales
Single-cell QTL resources and haplotype-aware fine-mapping now resolve variant effects by cell type and locus, beyond bulk single-variant estimates.
Single-cell
Segmentation and normalization methods refine brain single-cell and spatial profiling
Segmentation accuracy and normalization choices in brain single-cell and spatial data now bear directly on Alzheimer's-related inference.
Structural bio & protein design
Ensemble and free-energy methods now resolve RNA, protein and ligand binding physics
New REST2 RNA ensemble data, end-state free-energy tools and quantum-walk residue analysis appear across RNA and protein systems.
ML / AI methods
Baseline, endpoint, and reference choices shape reported gains in biomedical ML
Recent preprints audit evaluation design itself, finding that baselines, degree-matching, and measurement models change which reported gains hold up.