Top 40
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Structural bio & protein design
Structure prediction coupled to sampling and optimization for de novo biomolecular design
Recent preprints pair structure predictors and generative design with MD and physics-based scoring to validate binders and ligands.
Genomics
Variant effects on gene expression and chromatin mapped across immune cell types
Large single-cell and biobank-scale datasets now resolve variant effects on immune expression and chromatin at cell-type resolution.
Tools & infrastructure
Curated databases link spatial and single-cell omics to regulatory and cellular states
Spatial and single-cell measurements from hundreds of studies are now harmonized into searchable, interactive resources for reuse.
ML / AI methods
Neural representations tested against editing, interpretability, and transfer criteria
Recent preprints test learned models of neural and neurovascular data against editing, transfer, and interpretability criteria rather than predictive fit alone.
Tools & infrastructure
Open workflows for cell segmentation and spatial omics analysis across tissue datasets
Fine-tuned segmentation and community-built frameworks now target the segmentation bottleneck that limits spatial omics analysis at population scale.