Top 40
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Structural bio & protein design
Structure prediction coupled to learning drives biomolecular design and scoring
Closed-loop and search-reformulation methods now pair predictors with optimization to generate and score binders, enzymes, and antibodies.
Genomics
New association methods model admixed ancestry, haplotypes, and overlapping variants
Association and heritability frameworks are being extended to admixed ancestries and overlapping variant representations in biobank and GWAS data.
Single-cell
Computational frameworks resolve cell, isoform and allele assignment in sequencing data
Single-cell and long-read resources increasingly formalize cell identity and reference handling before biological inference.
Single-cell
Local geometry and graph topology inform single-cell dynamics inference
Geometry-aware flow matching and topology-based models now tie spatial context to single-cell trajectories, fate, and perturbation response.
Structural bio & protein design
Learned representations predict protein interactions, binding affinity, and function
Structure-aware models now target interfaces, binding affinity, and glycan complexes, while one study shows random splits inflate accuracy.