Top 40
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Single-cell
Computational methods infer cell states and niches from single-cell and spatial omics
Pretraining at 231 million profiles, multi-omics trajectory models and spatial deconvolution extend single-cell analysis to larger scales.
Genomics
Benchmarks against truth sets are defining somatic and structural variant detection
SMaHT and multi-institution studies release shared cell-line mixtures and synthetic resources to test low-allele-fraction somatic calling across platforms.
Epigenomics
Genome signatures link repair deficiency, amplicons and clonal architecture in tumors
Sequencing data from tumors and cfDNA now resolve repair-deficiency signatures, focal amplifications and subclonal architecture at higher resolution.
Tools & infrastructure
Open pipelines standardise biomedical image and qPCR data for reproducible analysis
Four preprints release open, browser or cloud tools that curate, quality-control, and quantify laboratory imaging and expression data.
ML / AI methods
AI agents orchestrate bioinformatics pipelines with verifiable tool execution and…
Recent preprints benchmark and deploy LLM agents across bioinformatics, screening, chemistry and breeding workflows, testing their reliability and added value.