Top 40
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Single-cell
Models infer cell fate, spatial organization and drug response from single-cell profiles
Recent preprints and papers extend single-cell inference to pretraining on 231 million profiles and subcellular spatial transcriptomics.
ML / AI methods
Evaluation design, not model choice alone, governs imputation and harmonization validity
Recent preprints score imputation and harmonization with alert-set, held-out, and cross-batch metrics instead of point accuracy alone.
Genomics
Shared reference resources benchmark somatic variant detection at low allele fractions
Multi-platform truth datasets and synthetic reference resources now allow somatic mutation callers to be benchmarked across sequencing technologies and low…
Systems biology
Recurrent connectivity trades capacity against stability in simulated neural circuits
Tools for extracting and validating low-dimensional neural dynamics now accompany new accounts of rotational and reciprocity-constrained circuit computation.
Genomics
Mutation signatures expose repair defects and platinum damage in cancer genomes
Whole-genome and long-read sequencing now resolve repair-deficiency, platinum, and amplification signatures across cancer cohorts.