Top 40
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Genomics
Cross-platform benchmarks reshape somatic and structural variant detection standards
Multi-platform truth sets and cell-line mixtures now benchmark somatic mutation and structural variant callers at low allele fractions.
Single-cell
Computational inference of cell-level and spatial structure from single-cell omics
Multi-slice atlases, multi-platform benchmarks, and paired multi-omics now demand methods that resolve cell-level and spatial structure jointly.
Single-cell
Single-cell and bulk transcriptome methods link cell states to drug prioritization
Single-cell resolution is increasingly carried into gene-set analysis, deconvolution, target ranking, and drug prioritization workflows.
ML / AI methods
Deep learning models predict and design nucleic acid function and editing outcomes
Recent preprints couple sequence with chromatin, structure, or high-throughput variant data to predict editing, binding, and designed RNA function.
Structural bio & protein design
Stricter benchmarks expose failure modes in structure-based binder and ligand design
Docking, binder design, and interface prediction are being re-evaluated under held-out, budgeted, and diagnostic protocols.