Top 40
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Structural bio & protein design
Benchmarks expose limits of co-folding and docking for ligand pose and pocket prediction
Co-folding models such as AF3, Boltz-2, and Chai-1 are now benchmarked prospectively, revealing out-of-distribution limits in ligand pose prediction.
Genomics
Benchmarking somatic and structural variant detection across sequencing platforms
Standardized benchmarks against truth sets and cell-line mixtures now expose platform- and caller-dependent accuracy in somatic and structural variant…
ML / AI methods
Reference and imputation choices shape biomedical ML agreement and recovery estimates
Evaluation outcomes in pathology, cytometry, ICU, and transcriptomic ML depend on reference labels, imputation, and harmonization choices.
Single-cell
Models infer cell states and interactions from spatial transcriptomic and histology data
Spatial single-cell methods now predict expression from histology and integrate multi-omics, but cross-patient transfer remains limited.
Transcriptomics
Methods extract cell-level and spatial transcriptomic structure from single-cell data
Aging, isoform usage, and multi-slice spatial atlases demand inference frameworks that resolve structure across cells, isoforms, and tissue scales.