Top 40
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Systems biology
Mechanistic models link enzyme allocation, growth limits and electron flux in cells
Quantitative models now resolve enzyme allocation, electron flux, and growth constraints across microbes, yeast, and optogenetic bioprocesses.
Structural bio & protein design
Tools for cryo-EM fitting, MD refinement, and biomolecular structure prediction
Recent preprints pair cryo-EM density fitting and differentiable restraints with force-field refinement against NMR and SAXS data.
Single-cell
Computational tools refine cell segmentation and spatial molecular state inference
Subcellular-resolution spatial transcriptomics methods now demand computational tools for foci detection, cell segmentation and clustering stability.
Single-cell
Biological priors built into models of single-cell perturbation and cell-state dynamics
Recent single-cell studies couple graph, transport, Bayesian, and physics-informed priors with multimodal and spatial data to predict perturbation responses.
Genomics
Graph, alignment, and language-model tools refine genome assembly and annotation
Four new preprints apply DNA language models and sequence-matching methods to assembly, horizontal transfer, and enzyme discovery tasks.