Top 40
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Structural bio & protein design
Structural tools span complex selection, RNA prediction and ligand binding-site mapping
Recent publications and preprints report accuracy-focused methods for complex model selection, structure search and binding-site prediction.
Tools & infrastructure
Open tools standardize, benchmark, and reprocess sequence data for reproducible biology
Public sequence resources are now reprocessed through automated, version-controlled pipelines with explicit standards for inputs and comparisons.
Single-cell
Established genomics frameworks are adapted to new single-cell and noisy data types
Growing atlas, cross-platform proteomics, and high-throughput assay scale demand methods robust to noise, batch effects, and platform differences.
Genomics
Scalable k-mer, graph, and learned methods extend genome and protein annotation
Recent preprints and publications extend annotation to pangenome graphs, bacterial protein families, and reference-free phylogenomic alignment.
Transcriptomics
Computational frameworks resolve cell types and anatomy in spatial transcriptomics data
Benchmarking 371 preprocessing workflows across 11 spatial platforms shows platform-specific choices shape downstream spatial transcriptomics analysis.