Top 40
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Structural bio & protein design
Tools for macromolecular structure preparation, comparison, search and model selection
New tools pair language-model embeddings and memory-safe, browser-deployable code with faster structure search and complex model selection.
Tools & infrastructure
Open-source tools for normalizing and quantifying high-throughput genomic datasets
Recent published tools address normalization, scalability, and quantification across MAVE, single-cell, transposable element, and epigenomic datasets.
Single-cell
Biological structure built into models for single-cell and spatial omics analysis
Prior biological structure is encoded in model architectures and objectives across single-cell and spatial omics rather than applied post hoc.
Single-cell
Biology-structured latent spaces guide single-cell perturbation and transition modeling
Recent preprints and two published papers embed invariant, mechanistic, or regulatory structure into single-cell generative and representation models.
ML / AI methods
Protein and DNA language models gain from injected evolutionary and structural priors
Recent preprints and publications test structure-injected protein language models on fitness, stability, and deployment constraints.