Top 40
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Tools & infrastructure
Reference database contamination and new pipelines reshape microbial genomic analysis
Widely used rRNA reference databases are shown to carry LSU contamination that misassigns metatranscriptomic reads, and cleaned versions are now supplied.
Single-cell
Generalizable models of regulatory DNA and single-cell perturbation responses
Preprints and publications now test whether sequence and perturbation models generalize and expose biologically interpretable internal structure.
Single-cell
Single-cell atlases and computational tools resolve tissue regulation and aging
Multi-omic and spatial single-cell resources now span lifespan, species and disease, with new tools for spatial gradients and evolutionary inference.
Transcriptomics
Computational frameworks link spatial transcriptomics to tissue geometry and histology
Spatial transcriptomics increasingly pairs gene expression with histology and tissue geometry, requiring models that encode these coordinates directly.
Genomics
Haplotype-resolved pangenome assemblies expand human variation and ancestry inference
Near-complete, phased assemblies now resolve centromeres, East Asian diversity, and pangenome-scale common variation in population samples.