Top 40
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Structural bio & protein design
Learned structure models are being applied to binder design, co-folding, and stability
Recent preprints and two peer-reviewed benchmarks test structure-aware models for co-folding, inverse folding, and binding prediction.
Transcriptomics
Histology-to-spatial omics models infer gene expression from routine H&E sections
Spatial omics is now distilled into models operating on routine H&E, enabling transcriptomic inference from widely available histology.
Single-cell
Generative models infer single-cell dynamics, transitions and perturbation responses
Growing multimodal, spatial and time-resolved single-cell datasets demand models that jointly infer cell states, dynamics and perturbation responses.
Epigenomics
Deep models and epigenome annotation infer regulatory elements from chromatin data
Foundation and segmentation models now couple DNA sequence, methylation, histone marks and accessibility to predict regulatory elements and states.
Tools & infrastructure
Scalable tools benchmark genome alignment, assembly, and phylogenetic inference methods
Recent preprints and a published OrthoFinder extension target runtime, memory, and accuracy limits in large-scale genome comparison.