Top 40
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Structural bio & protein design
Deep models gain experimental restraints and geometric priors for biomolecular design
Recent preprints pair pretrained structure and language models with XL-MS, HDX-MS, and surface-geometry constraints for design and prediction.
Transcriptomics
Spatial omics resolves niche communication, recruitment, and multiscale tissue topology
Spatial omics methods now infer communication motifs, niche recruitment, and perturbation phenotypes directly in tissue context.
Single-cell
Computational frameworks couple perturbation screens to single-cell multimodal readouts
Optical pooled and multimodal single-cell chemical screens now generate terabyte-scale, multi-readout data that require scalable analysis.
ML / AI methods
Comparisons of biomolecular AI models expose thermodynamic and conformational determinants
Recent preprints and a published pKa study probe whether learned representations capture physical quantities, not only sequence patterns.
Genomics
Structural variants, polygenic axes and mtDNA regulation across genomic scales
Rare-variant GWAS confounding and mtDNA expression decoupling are refining how genomic variation is linked to function and trait architecture.