Top 40
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Single-cell
Pooled CRISPR screens and spatial transcriptomics resolve perturbation effects in tissue
Perturb-seq and spatial platforms now couple CRISPR perturbations to single-cell and morphological readouts, demanding new statistical tools.
Structural bio & protein design
Learned models generate, score, and steer biomolecular structures and sequences
Pretrained protein language models and structure-aware networks are now being coupled to experimental restraints and explicit design constraints.
Genomics
Benchmarks and new callers refine variant, indel, and fusion detection
Pangenome graph references and GIAB-benchmarked platforms are now being applied to somatic, complex indel, and fusion variant calling.
Genomics
Host-linked genomic structure across coral, plant, protist, and viral systems
Recent preprints and a 2026 publication pair genome-scale profiling with host genetics and population sampling across diverse taxa.
ML / AI methods
ML frameworks infer cell, tissue, and repertoire states from omics and imaging data
Recent work pairs graph transfer learning, foundation-model attributions, and explainable ML with spatial, single-cell, and repertoire data.