Top 40
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Genomics
Improved variant calling across short-read, long-read, and low-pass sequencing data
Long-read references and mixed-platform sequencing now enable structural variant GWAS, metagenomic SNP calling, and clinical copy number inference.
ML / AI methods
Multimodal and graph-based models link enzymes, reactions, E3 ligases, and PPIs
Recent work fuses protein language model embeddings, predicted structures, and graph learning across enzyme, PPI, and effector prediction tasks.
ML / AI methods
LLM agents generate and code-verify biological analysis methods and discoveries
Recent preprints and two published papers report LLM agent systems that automate bioinformatics, sequencing, and spatial omics analysis with verification.
Proteomics
Joint batch correction and imputation in proteomics via matrix factorization
Batch correction and missing-value handling are being modelled within a single framework rather than as sequential preprocessing steps.
Single-cell
Single-cell multi-omic layers map age, disease, and senescence regulatory states
Regulatory and transcript-architecture layers are now profiled at individual-cell and locus resolution across aging, disease, and senescence.