Top 40
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Tools & infrastructure
Software tools correct technical artifacts and reuse public omics data at scale
Large public datasets and platform artifacts, such as Xenium off-target probe binding, make validated reuse and quality control tooling essential.
ML / AI methods
Sequence-based models advance protein and peptide structure and function prediction
Recent 2026 papers test protein language model embeddings, fine-tuned architectures and fingerprints across peptide, TCR, HIV and structure tasks.
ML / AI methods
Deep learning models forecast perturbation effects, drug synergy, and binding affinity
Knowledge graphs, multi-omics data, and pretrained language-model embeddings are now being fused to predict perturbation, synergy, and binding outcomes.
Single-cell
New algorithms reconstruct 3D spatial omics and resolve cell-level spatial features
Spatial and single-cell datasets increasingly require methods that handle 3D structure, sparse maps, and multi-sample designs.
Genomics
Long-read tools refine small variant, indel, HLA and structural variant calling
Long-read sequencing now supports accelerated, benchmarked variant calling across SNVs, indels, HLA alleles and structural rearrangements.