Top 40
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Single-cell
Single-cell models and causal methods test transferable gene regulatory knowledge
Evaluation under distribution shift, rather than in-distribution accuracy, is now used to test whether foundation models retain regulatory knowledge.
Tools & infrastructure
Heterogeneous-model and raw-read phylogenetics tools advance evolutionary inference
Mixture models fit heterogeneous phylogenomic data best, and new software now spans raw reads, protein structure, and gene concordance.
Epigenomics
Benchmarking frameworks compare single-cell, spatial and 3D genome omics methods
Matched multi-platform datasets and 23-model benchmarks now test omic integration and spatial platform performance directly.
Genomics
GWAS associations are integrated into genomic and phenotype prediction frameworks
GAPIT v4 reports over 20% accuracy gain over GBLUP, as preprints extend GWAS to drug target support and migraine prediction.
Proteomics
Software and databases address missing values, probe artifacts and public data reuse
Recent tools target quantitative accuracy in DIA proteomics, spatial transcriptomic probe specificity and large-scale reuse of public transcriptomic and…