Top 40
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Transcriptomics
Computational methods place gene expression and cell arrangement within tissue geometry
Spatial omics methods now address 3D reconstruction, differential co-localisation, and subcellular mRNA localization in tissue context.
Single-cell
Atlases attribute genetic risk and developmental state to individual cell types
Harmonized human single-cell atlases now span millions of cells, enabling uniform cross-dataset comparison of genetic and developmental effects at cell-type…
Structural bio & protein design
RL-steered generative models expand controllable molecule and antibody design
Recent preprints and papers couple generative models with reinforcement learning and Bayesian optimization for explicit design goals.
Systems biology
Perturbation screens coupled to genome, morphology and transcriptome readouts
Screens now pair large perturbation sets with multimodal or single-cell readouts across neural, cardiac, and melanoma models.
ML / AI methods
Metabolic models and protein language models predict microbial and phage traits
Genome-scale metabolic models and protein language models now target interaction specificity and intervention targets, not only sequence annotation.