Top 40
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Structural bio & protein design
Conditioned generators steer molecule, protein and RNA design toward explicit objectives
Recent preprints and publications pair diffusion, language-model and reinforcement learning generators with explicit design objectives across small molecules,…
Structural bio & protein design
Computational screening and generative design narrow candidate spaces before experimental…
Large candidate spaces for binders and drug targets are now pre-filtered computationally before experimental validation.
ML / AI methods
ML models link tissue-level histology and spatial profiles to clinical outcomes
Precomputed tumor microenvironment resources and outcome-oriented models now address tissue features tied to recurrence, survival, and immunotherapy response.
Single-cell
Linking single-cell chromatin and spatial context to regulatory inference
Multi-omic and spatial single-cell methods now aim to tie regulatory models to chromatin, neighborhood and communication context, not expression alone.
Genomics
Computational assessment of variant effects across stability, dosage, and development
Recent work quantifies variant consequences via clinical calibration, interactome free-energy, molecular dynamics, and tissue-level dosage metrics.