Top 40
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Structural bio & protein design
Diffusion and LLM generators steer molecule design toward shape and property goals
Recent preprints and papers apply RL steering and 3D conditioning to diffusion and language-model generators for goal-directed design.
Single-cell
Atlases attribute genetic risk and developmental programs to individual cell types
Single-cell atlases now span millions of human cells, enabling cell-type-resolved mapping of disease genetics and developmental age.
Structural bio & protein design
Structure-aware pipelines prioritize binders and ligands ahead of experimental validation
Structure-based design and screening tools are being integrated directly into candidate prioritization ahead of wet-lab validation.
Single-cell
Tying chromatin accessibility and spatial context to single-cell regulatory inference
Single-cell multiomic and spatial tools now tie chromatin and tissue context to gene regulation, with benchmarks testing integration choices.
ML / AI methods
Multimodal fusion of sequence, structure and dynamics for protein and RNA prediction
Recent preprints and papers pair learned sequence, structure, and dynamics embeddings with graph models to predict protein function, binding, and fitness.